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Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b

Sialic acid-binding Ig-like lectin 15 (Siglec-15) is an immune modulator and emerging cancer immunotherapy target. However, limited understanding of its structure and mechanism of action restrains the development of drug candidates that unleash its full therapeutic potential. In this study, we eluci...

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Detalles Bibliográficos
Autores principales:	Lenza, Maria Pia, Egia-Mendikute, Leire, Antoñana-Vildosola, Asier, Soares, Cátia O., Coelho, Helena, Corzana, Francisco, Bosch, Alexandre, Manisha, Prodhi, Quintana, Jon Imanol, Oyenarte, Iker, Unione, Luca, Moure, María Jesús, Azkargorta, Mikel, Atxabal, Unai, Sobczak, Klaudia, Elortza, Felix, Sutherland, James D., Barrio, Rosa, Marcelo, Filipa, Jiménez-Barbero, Jesús, Palazon, Asis, Ereño-Orbea, June
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264397/ https://www.ncbi.nlm.nih.gov/pubmed/37311743 http://dx.doi.org/10.1038/s41467-023-39119-8

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