Embryonic vitamin D deficiency programs hematopoietic stem cells to induce type 2 diabetes

Environmental factors may alter the fetal genome to cause metabolic diseases. It is unknown whether embryonic immune cell programming impacts the risk of type 2 diabetes in later life. We demonstrate that transplantation of fetal hematopoietic stem cells (HSCs) made vitamin D deficient in utero indu...

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Detalles Bibliográficos
Autores principales: Oh, Jisu, Riek, Amy E., Bauerle, Kevin T., Dusso, Adriana, McNerney, Kyle P., Barve, Ruteja A., Darwech, Isra, Sprague, Jennifer E., Moynihan, Clare, Zhang, Rong M., Kutz, Greta, Wang, Ting, Xing, Xiaoyun, Li, Daofeng, Mrad, Marguerite, Wigge, Nicholas M., Castelblanco, Esmeralda, Collin, Alejandro, Bambouskova, Monika, Head, Richard D., Sands, Mark S., Bernal-Mizrachi, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264405/
https://www.ncbi.nlm.nih.gov/pubmed/37311757
http://dx.doi.org/10.1038/s41467-023-38849-z

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