Chimaeric plant-produced bluetongue virus particles as potential vaccine candidates

Bluetongue virus (BTV) causes bluetongue disease in ruminants and sheep. The current live attenuated and inactivated vaccines available for prevention pose several risks, and there is thus a need for vaccines that are safer, economically viable, and effective against multiple circulating serotypes....

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Detalles Bibliográficos
Autores principales: Gwynn, A., Mbewana, S., Lubisi, B. A., Tshabalala, H. M., Rybicki, E. P., Meyers, A. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264491/
https://www.ncbi.nlm.nih.gov/pubmed/37310539
http://dx.doi.org/10.1007/s00705-023-05790-x
Descripción
Sumario:Bluetongue virus (BTV) causes bluetongue disease in ruminants and sheep. The current live attenuated and inactivated vaccines available for prevention pose several risks, and there is thus a need for vaccines that are safer, economically viable, and effective against multiple circulating serotypes. This work describes the development of recombinant virus-like particle (VLP) vaccine candidates in plants, which are assembled by co-expression of the four BTV serotype 8 major structural proteins. We show that substitution of a neutralising tip domain of BTV8 VP2 with that of BTV1 VP2 resulted in the assembly of VLPs that stimulated serotype-specific antibodies as well as virus-specific neutralising antibodies. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00705-023-05790-x.

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