The 27-gene IO score is associated with efficacy of PD-1/L1 inhibitors independent of FGFR expression in a real-world metastatic urothelial carcinoma cohort

Multiple targeted therapeutics have been approved by the FDA for mUC, including immune checkpoint inhibitors (ICIs) and more recently targeted agents for both FGFR and Nectin-4. FGFR3-aberrant and Nectin-4 expressing cells have been associated with an immunosuppressed phenotype. Given that less than...

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Detalles Bibliográficos
Autores principales: Nielsen, Tyler J., Varga, Matthew G., Cronister, Catherine T., Ring, Brian Z., Seitz, Robert S., Ross, Douglas T., Schweitzer, Brock L., McGregor, Kimberly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264529/
https://www.ncbi.nlm.nih.gov/pubmed/36806983
http://dx.doi.org/10.1007/s00262-023-03401-x

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