CD33 BiTE(®) molecule-mediated immune synapse formation and subsequent T-cell activation is determined by the expression profile of activating and inhibitory checkpoint molecules on AML cells

Bispecific T-cell engager (BiTE(®)) molecules recruit T cells to cancer cells through CD3ε binding, independently of T-cell receptor (TCR) specificity. Whereas physiological T-cell activation is dependent on signal 1 (TCR engagement) and signal 2 (co-stimulation), BiTE molecule-mediated T-cell activ...

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Detalles Bibliográficos
Autores principales: Marcinek, Anetta, Brauchle, Bettina, Rohrbacher, Lisa, Hänel, Gerulf, Philipp, Nora, Märkl, Florian, Strzalkowski, Thaddäus, Lacher, Sonja M., Udiljak, Dragica, Spiekermann, Karsten, Theurich, Sebastian, Kobold, Sebastian, Kischel, Roman, James, John R., Bücklein, Veit L., Subklewe, Marion
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264534/
https://www.ncbi.nlm.nih.gov/pubmed/37041225
http://dx.doi.org/10.1007/s00262-023-03439-x

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