Cargando…

Glycomimetic antagonists of BC2L-C lectin: insights from molecular dynamics simulations

Opportunistic infections from multidrug-resistant pathogens such as Burkholderia cenocepacia are a threatening risk for hospital-bound patients suffering from immunocompromised conditions or cystic fibrosis. B. cenocepacia BC2L-C lectin has been linked to bacterial adhesion and biofilm formation, th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Antonini, Giulia, Civera, Monica, Lal, Kanhaya, Mazzotta, Sarah, Varrot, Annabelle, Bernardi, Anna, Belvisi, Laura
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264699/ https://www.ncbi.nlm.nih.gov/pubmed/37325481 http://dx.doi.org/10.3389/fmolb.2023.1201630

Ejemplares similares

Identification of New L-Fucosyl and L-Galactosyl Amides as Glycomimetic Ligands of TNF Lectin Domain of BC2L-C from Burkholderia cenocepacia
por: Mazzotta, Sarah, et al.
Publicado: (2023)

Targeting a Multidrug-Resistant Pathogen: First Generation Antagonists of Burkholderia cenocepacia’s BC2L-C Lectin
por: Bermeo, Rafael, et al.
Publicado: (2022)

Non‐Carbohydrate Glycomimetics as Inhibitors of Calcium(II)‐Binding Lectins
por: Kuhaudomlarp, Sakonwan, et al.
Publicado: (2021)

BC2L-C N-Terminal Lectin Domain Complexed with Histo Blood Group Oligosaccharides Provides New Structural Information
por: Bermeo, Rafael, et al.
Publicado: (2020)

Glycomimetics for the inhibition and modulation of lectins
por: Leusmann, Steffen, et al.
Publicado: (2023)

Prediction and Validation of a Druggable Site on Virulence Factor of Drug Resistant Burkholderia cenocepacia
por: Lal, Kanhaya, et al.
Publicado: (2021)

Genomic Rearrangements and Functional Diversification of lecA and lecB Lectin-Coding Regions Impacting the Efficacy of Glycomimetics Directed against Pseudomonas aeruginosa
por: Boukerb, Amine M., et al.
Publicado: (2016)

Homology Model of a Catalytically Competent Bifunctional Rel Protein
por: Civera, Monica, et al.
Publicado: (2021)

Structural Diversities of Lectins Binding to the Glycosphingolipid Gb3
por: Siukstaite, Lina, et al.
Publicado: (2021)

On‐Chip Screening of a Glycomimetic Library with C‐Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin‐2 over DC‐SIGN/R and Langerin
por: Medve, Laura, et al.
Publicado: (2018)

Recent Advances in Lectin-Based Affinity Sorbents for Protein Glycosylation Studies
por: Goumenou, Anastasia, et al.
Publicado: (2021)

3D Structural View of Pathogen Recognition by Mammalian Lectin Receptors
por: Manabe, Noriyoshi, et al.
Publicado: (2021)

The Value of H2BC12 for Predicting Poor Survival Outcomes in Patients With WHO Grade II and III Gliomas
por: Zhou, Jie, et al.
Publicado: (2022)

Structural insights into the binding of zoledronic acid with RANKL via computational simulations
por: Wang, Ruijie, et al.
Publicado: (2022)

Editorial: Peptides Targeting Protein-Protein Interactions: Methods and Applications
por: Belvisi, Laura, et al.
Publicado: (2021)

DNA Polymerase Conformational Dynamics and the Role of Fidelity-Conferring Residues: Insights from Computational Simulations
por: Meli, Massimiliano, et al.
Publicado: (2016)

Insight Into Seeded Tau Fibril Growth From Molecular Dynamics Simulation of the Alzheimer’s Disease Protofibril Core
por: Leonard, Cass, et al.
Publicado: (2021)

The Leukotriene Receptor Antagonist Montelukast as a Potential COVID-19 Therapeutic
por: Aigner, Ludwig, et al.
Publicado: (2020)

Is Crocin a Potential Anti-tumor Candidate Targeting Microtubules? Computational Insights From Molecular Docking and Dynamics Simulations
por: Wang, Ze, et al.
Publicado: (2020)

New Insights into Vaginal Environment During Pregnancy
por: Marangoni, Antonella, et al.
Publicado: (2021)

Editorial: Enzymes Regulating the Homeostasis of Agonists and Antagonists of the N-Methyl D-Aspartate Receptors
por: Mozzarelli, Andrea, et al.
Publicado: (2019)

Editorial: Multiscale Modeling From Macromolecules to Cell: Opportunities and Challenges of Biomolecular Simulations
por: Palermo, Giulia, et al.
Publicado: (2020)

Life stage-specific glycosylation of extracellular vesicles from Schistosoma mansoni schistosomula and adult worms drives differential interaction with C-type lectin receptors DC-SIGN and MGL
por: Kuipers, Marije E., et al.
Publicado: (2023)

Designer Leptin Receptor Antagonist Allo-aca Inhibits VEGF Effects in Ophthalmic Neoangiogenesis Models
por: Coroniti, Roberta, et al.
Publicado: (2016)

Antagonistic Control of Genetic Circuit Performance for Rapid Analysis of Targeted Enzyme Activity in Living Cells
por: Kwon, Kil Koang, et al.
Publicado: (2021)

Targeting Galectins With Glycomimetics
por: Bertuzzi, Sara, et al.
Publicado: (2020)

Comparative Molecular Dynamics Simulations Provide Insight Into Antibiotic Interactions: A Case Study Using the Enzyme L,L-Diaminopimelate Aminotransferase (DapL)
por: Adams, Lily E., et al.
Publicado: (2020)

Corrigendum: Designer Leptin Receptor Antagonist Allo-aca Inhibits VEGF Effects in Ophthalmic Neoangiogenesis Models
por: Coroniti, Roberta, et al.
Publicado: (2016)

The Specific NLRP3 Antagonist IFM-514 Decreases Fibrosis and Inflammation in Experimental Murine Non-Alcoholic Steatohepatitis
por: Torres, Sandra, et al.
Publicado: (2021)

Druggable Allosteric Sites in β‐Propeller Lectins
por: Shanina, Elena, et al.
Publicado: (2021)

Enhancer-Promoter Communication: It’s Not Just About Contact
por: Wurmser, Annabelle, et al.
Publicado: (2022)

Investigation of TNBC in vitro Antiproliferative Effects of Versatile Pirrolo[1,2-a]quinoxaline Compounds
por: Perri, Mariarita, et al.
Publicado: (2019)

Editorial: Machine Learning in Biomolecular Simulations
por: Verkhivker, Gennady, et al.
Publicado: (2019)

Modeling Crowded Environment in Molecular Simulations
por: Ostrowska, Natalia, et al.
Publicado: (2019)

Potential antagonistic relationship of fgf9 and rspo1 genes in WNT4 pathway to regulate the sex differentiation in Chinese giant salamander (Andrias davidianus)
por: Zhang, Jiankang, et al.
Publicado: (2022)

Accurate Biomolecular Simulations Account for Electronic Polarization
por: Melcr, Josef, et al.
Publicado: (2019)

New Insights on Ferroptosis and Gynecological Malignancies
por: Fan, Ruiqi, et al.
Publicado: (2022)

Structural and evolutionary insights into astacin metallopeptidases
por: Gomis-Rüth, F. Xavier, et al.
Publicado: (2023)

Editorial: Insights in Structural Biology: 2021
por: Alfano, Caterina, et al.
Publicado: (2022)

Editorial: Insights into RNA networks and biology
por: Gerber, André P., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_d4lh4pndu4gh8a8a4o5tqelbcq