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Early changes in cerebral metabolism after perinatal hypoxia-ischemia: a study in normothermic and hypothermic piglets
INTRODUCTION: Hypoxic ischemic encephalopathy (HIE) after a perinatal insult is a dynamic process that evolves over time. Therapeutic hypothermia (TH) is standard treatment for severe to moderate HIE. There is a lack of evidence on the temporal change and interrelation of the underlying mechanisms t...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264796/ https://www.ncbi.nlm.nih.gov/pubmed/37325341 http://dx.doi.org/10.3389/fped.2023.1167396 |
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author | Andelius, Ted C. K. Bøgh, Nikolaj Pedersen, Mette V. Omann, Camilla Andersen, Mads Andersen, Hannah B. Hjortdal, Vibeke E. Pedersen, Michael Rasmussen, Martin B. Kyng, Kasper J. Henriksen, Tine B. |
author_facet | Andelius, Ted C. K. Bøgh, Nikolaj Pedersen, Mette V. Omann, Camilla Andersen, Mads Andersen, Hannah B. Hjortdal, Vibeke E. Pedersen, Michael Rasmussen, Martin B. Kyng, Kasper J. Henriksen, Tine B. |
author_sort | Andelius, Ted C. K. |
collection | PubMed |
description | INTRODUCTION: Hypoxic ischemic encephalopathy (HIE) after a perinatal insult is a dynamic process that evolves over time. Therapeutic hypothermia (TH) is standard treatment for severe to moderate HIE. There is a lack of evidence on the temporal change and interrelation of the underlying mechanisms that constitute HIE under normal and hypothermic conditions. We aimed to describe early changes in intracerebral metabolism after a hypoxic-ischemic insult in piglets treated with and without TH and in controls. METHODS: Three devices were installed into the left hemisphere of 24 piglets: a probe measuring intracranial pressure, a probe measuring blood flow and oxygen tension, and a microdialysis catheter measuring lactate, glucose, glycerol, and pyruvate. After a standardized hypoxic ischemic insult, the piglets were randomized to either TH or normothermia. RESULTS: Glycerol, a marker of cell lysis, increased immediately after the insult in both groups. There was a secondary increase in glycerol in normothermic piglets but not in piglets treated with TH. Intracerebral pressure, blood flow, oxygen tension, and extracellular lactate remained stable during the secondary increase in glycerol. CONCLUSION: This exploratory study depicted the development of the pathophysiological mechanisms in the hours following a perinatal hypoxic-ischemic insult with and without TH and controls. |
format | Online Article Text |
id | pubmed-10264796 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102647962023-06-15 Early changes in cerebral metabolism after perinatal hypoxia-ischemia: a study in normothermic and hypothermic piglets Andelius, Ted C. K. Bøgh, Nikolaj Pedersen, Mette V. Omann, Camilla Andersen, Mads Andersen, Hannah B. Hjortdal, Vibeke E. Pedersen, Michael Rasmussen, Martin B. Kyng, Kasper J. Henriksen, Tine B. Front Pediatr Pediatrics INTRODUCTION: Hypoxic ischemic encephalopathy (HIE) after a perinatal insult is a dynamic process that evolves over time. Therapeutic hypothermia (TH) is standard treatment for severe to moderate HIE. There is a lack of evidence on the temporal change and interrelation of the underlying mechanisms that constitute HIE under normal and hypothermic conditions. We aimed to describe early changes in intracerebral metabolism after a hypoxic-ischemic insult in piglets treated with and without TH and in controls. METHODS: Three devices were installed into the left hemisphere of 24 piglets: a probe measuring intracranial pressure, a probe measuring blood flow and oxygen tension, and a microdialysis catheter measuring lactate, glucose, glycerol, and pyruvate. After a standardized hypoxic ischemic insult, the piglets were randomized to either TH or normothermia. RESULTS: Glycerol, a marker of cell lysis, increased immediately after the insult in both groups. There was a secondary increase in glycerol in normothermic piglets but not in piglets treated with TH. Intracerebral pressure, blood flow, oxygen tension, and extracellular lactate remained stable during the secondary increase in glycerol. CONCLUSION: This exploratory study depicted the development of the pathophysiological mechanisms in the hours following a perinatal hypoxic-ischemic insult with and without TH and controls. Frontiers Media S.A. 2023-05-31 /pmc/articles/PMC10264796/ /pubmed/37325341 http://dx.doi.org/10.3389/fped.2023.1167396 Text en © 2023 Andelius, Bøgh, Pedersen, Omann, Andersen, Andersen, Hjortdal, Pedersen, Rasmussen, Kyng and Henriksen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics Andelius, Ted C. K. Bøgh, Nikolaj Pedersen, Mette V. Omann, Camilla Andersen, Mads Andersen, Hannah B. Hjortdal, Vibeke E. Pedersen, Michael Rasmussen, Martin B. Kyng, Kasper J. Henriksen, Tine B. Early changes in cerebral metabolism after perinatal hypoxia-ischemia: a study in normothermic and hypothermic piglets |
title | Early changes in cerebral metabolism after perinatal hypoxia-ischemia: a study in normothermic and hypothermic piglets |
title_full | Early changes in cerebral metabolism after perinatal hypoxia-ischemia: a study in normothermic and hypothermic piglets |
title_fullStr | Early changes in cerebral metabolism after perinatal hypoxia-ischemia: a study in normothermic and hypothermic piglets |
title_full_unstemmed | Early changes in cerebral metabolism after perinatal hypoxia-ischemia: a study in normothermic and hypothermic piglets |
title_short | Early changes in cerebral metabolism after perinatal hypoxia-ischemia: a study in normothermic and hypothermic piglets |
title_sort | early changes in cerebral metabolism after perinatal hypoxia-ischemia: a study in normothermic and hypothermic piglets |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264796/ https://www.ncbi.nlm.nih.gov/pubmed/37325341 http://dx.doi.org/10.3389/fped.2023.1167396 |
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