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A life‐threatening case of pheochromocytoma crisis with hemodynamic instability

BACKGROUND: Pheochromocytoma crisis (PCC) is a fatal disease characterized by hyper and/or hypotension, hyperthermia, and encephalopathy, and its diagnosis and treatment are challenging. CASE PRESENTATION: A 50‐year‐old woman presented with hypertension, and computed tomography showed an adrenal tum...

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Autores principales: Taniguchi, Hiroaki, Kiriu, Nobuaki, Kato, Hiroshi, Kiyozumi, Tetsuro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264911/
https://www.ncbi.nlm.nih.gov/pubmed/37323563
http://dx.doi.org/10.1002/ams2.858
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author Taniguchi, Hiroaki
Kiriu, Nobuaki
Kato, Hiroshi
Kiyozumi, Tetsuro
author_facet Taniguchi, Hiroaki
Kiriu, Nobuaki
Kato, Hiroshi
Kiyozumi, Tetsuro
author_sort Taniguchi, Hiroaki
collection PubMed
description BACKGROUND: Pheochromocytoma crisis (PCC) is a fatal disease characterized by hyper and/or hypotension, hyperthermia, and encephalopathy, and its diagnosis and treatment are challenging. CASE PRESENTATION: A 50‐year‐old woman presented with hypertension, and computed tomography showed an adrenal tumor. Fever, shock, and impaired consciousness were observed, and PCC was diagnosed clinically. Systolic blood pressure fluctuated from 40–220 mmHg within a few minutes, and circulatory agonists were adjusted accordingly. The blood pressure changes gradually stabilized with α‐blockade. Surgery was performed on hospital day 26, and the pathological diagnosis was consistent with a pheochromocytoma. She was discharged on hospital day 37. CONCLUSION: Computed tomography may facilitate early diagnosis in the acute phase of PCC in case of limited patient medical information and insufficient time to wait for a definitive diagnosis using traditional hormone tests. The shock requires pharmacological therapy to maintain circulation, and paradoxically, the administration of α‐blockade can be lifesaving.
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spelling pubmed-102649112023-06-15 A life‐threatening case of pheochromocytoma crisis with hemodynamic instability Taniguchi, Hiroaki Kiriu, Nobuaki Kato, Hiroshi Kiyozumi, Tetsuro Acute Med Surg Case Report BACKGROUND: Pheochromocytoma crisis (PCC) is a fatal disease characterized by hyper and/or hypotension, hyperthermia, and encephalopathy, and its diagnosis and treatment are challenging. CASE PRESENTATION: A 50‐year‐old woman presented with hypertension, and computed tomography showed an adrenal tumor. Fever, shock, and impaired consciousness were observed, and PCC was diagnosed clinically. Systolic blood pressure fluctuated from 40–220 mmHg within a few minutes, and circulatory agonists were adjusted accordingly. The blood pressure changes gradually stabilized with α‐blockade. Surgery was performed on hospital day 26, and the pathological diagnosis was consistent with a pheochromocytoma. She was discharged on hospital day 37. CONCLUSION: Computed tomography may facilitate early diagnosis in the acute phase of PCC in case of limited patient medical information and insufficient time to wait for a definitive diagnosis using traditional hormone tests. The shock requires pharmacological therapy to maintain circulation, and paradoxically, the administration of α‐blockade can be lifesaving. John Wiley and Sons Inc. 2023-06-13 /pmc/articles/PMC10264911/ /pubmed/37323563 http://dx.doi.org/10.1002/ams2.858 Text en © 2023 The Authors. Acute Medicine & Surgery published by John Wiley & Sons Australia, Ltd on behalf of Japanese Association for Acute Medicine. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Case Report
Taniguchi, Hiroaki
Kiriu, Nobuaki
Kato, Hiroshi
Kiyozumi, Tetsuro
A life‐threatening case of pheochromocytoma crisis with hemodynamic instability
title A life‐threatening case of pheochromocytoma crisis with hemodynamic instability
title_full A life‐threatening case of pheochromocytoma crisis with hemodynamic instability
title_fullStr A life‐threatening case of pheochromocytoma crisis with hemodynamic instability
title_full_unstemmed A life‐threatening case of pheochromocytoma crisis with hemodynamic instability
title_short A life‐threatening case of pheochromocytoma crisis with hemodynamic instability
title_sort life‐threatening case of pheochromocytoma crisis with hemodynamic instability
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264911/
https://www.ncbi.nlm.nih.gov/pubmed/37323563
http://dx.doi.org/10.1002/ams2.858
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