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Non-natural amino acids into LfcinB-derived peptides: effect in their (i) proteolytic degradation and (ii) cytotoxic activity against cancer cells

The dimeric peptide (26)[F]: (RRWQWRFKKLG)(2)-K-Ahx has exhibited a potent cytotoxic effect against breast cancer cell lines, with position 26 (F) being the most relevant for anti-cancer activity. In this investigation, six analogues of the (26)[F] peptide were synthesized in which the 26th position...

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Detalles Bibliográficos
Autores principales:	Insuasty-Cepeda, Diego Sebastián, Barragán-Cárdenas, Andrea Carolina, Ardila-Chantre, Natalia, Cárdenas-Martínez, Karen Johanna, Rincón-Quiñones, Isabella, Vargas-Casanova, Yerly, Ochoa-Zarzosa, Alejandra, Lopez-Meza, Joel Edmundo, Parra-Giraldo, Claudia Marcela, Ospina-Giraldo, Luis Fernando, Fierro-Medina, Ricardo, García-Castañeda, Javier Eduardo, Rivera-Monroy, Zuly Jenny
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society 2023
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265003/ https://www.ncbi.nlm.nih.gov/pubmed/37325596 http://dx.doi.org/10.1098/rsos.221493

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