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Parkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson's disease

Microglial hyperactivation of the NOD‐, LRR‐, and pyrin domain‐containing 3 (NLRP3) inflammasome contributes to the pathogenesis of Parkinson's disease (PD). Recently, neuronally expressed NLRP3 was demonstrated to be a Parkin polyubiquitination substrate and a driver of neurodegeneration in PD...

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Detalles Bibliográficos
Autores principales:	Yan, Yi‐Qun, Zheng, Ran, Liu, Yi, Ruan, Yang, Lin, Zhi‐Hao, Xue, Nai‐Jia, Chen, Ying, Zhang, Bao‐Rong, Pu, Jia‐Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265164/ https://www.ncbi.nlm.nih.gov/pubmed/37029500 http://dx.doi.org/10.1111/acel.13834

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