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Clinical characteristics of acute kidney injury in patients with glyphosate surfactant herbicide poisoning
BACKGROUND: In this study, we investigated the clinical characteristics of acute kidney injury (AKI) in patients with glyphosate surfactant herbicide (GSH) poisoning. METHODS: This study was performed between 2008 and 2021 and included 184 patients categorized into the AKI (n = 82) and non-AKI (n =...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Society of Nephrology
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265214/ https://www.ncbi.nlm.nih.gov/pubmed/37098674 http://dx.doi.org/10.23876/j.krcp.22.051 |
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author | Cho, A Young Oh, Ju Hwan Oh, Sung Sik Lee, Kwang Young Sun, In O |
author_facet | Cho, A Young Oh, Ju Hwan Oh, Sung Sik Lee, Kwang Young Sun, In O |
author_sort | Cho, A Young |
collection | PubMed |
description | BACKGROUND: In this study, we investigated the clinical characteristics of acute kidney injury (AKI) in patients with glyphosate surfactant herbicide (GSH) poisoning. METHODS: This study was performed between 2008 and 2021 and included 184 patients categorized into the AKI (n = 82) and non-AKI (n = 102) groups. The incidence, clinical characteristics, and severity of AKI were compared between the groups based on the Risk of renal dysfunction, Injury to the kidney, Failure or Loss of kidney function, and End-stage kidney disease (RIFLE) classification. RESULTS: The incidence of AKI was 44.5%, of which 25.0%, 6.5%, and 13.0% of patients were classified into the Risk, Injury, and Failure categories, respectively. Patients in the AKI group were older (63.3 ± 16.2 years vs. 57.4 ± 17.5 years, p = 0.02) than those in the non-AKI group. The length of hospitalization was longer (10.7 ± 12.1 days vs. 6.5 ± 8.1 days, p = 0.004) and hypotensive episodes occurred more frequently in the AKI group (45.1% vs. 8.8%, p < 0.001). Electrocardiographic (ECG) abnormalities on admission were more frequently observed in the AKI group than in the non-AKI group (80.5% vs. 47.1%, p < 0.001). Patients in the AKI group had poorer renal function (estimated glomerular filtration rate at the time of admission, 62.2 ± 22.9 mL/min/1.73 m(2) vs. 88.9 ± 26.1 mL/min/1.73 m(2), p < 0.001) on admission. The mortality rate was higher in the AKI group than in the non-AKI group (18.3% vs. 1.0%, p < 0.001). Multiple logistic regression analysis showed that hypotension and ECG abnormalities upon admission were significant predictors of AKI in patients with GSH poisoning. CONCLUSION: The presence of hypotension on admission may be a useful predictor of AKI in patients with GSH intoxication. |
format | Online Article Text |
id | pubmed-10265214 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Korean Society of Nephrology |
record_format | MEDLINE/PubMed |
spelling | pubmed-102652142023-06-15 Clinical characteristics of acute kidney injury in patients with glyphosate surfactant herbicide poisoning Cho, A Young Oh, Ju Hwan Oh, Sung Sik Lee, Kwang Young Sun, In O Kidney Res Clin Pract Original Article BACKGROUND: In this study, we investigated the clinical characteristics of acute kidney injury (AKI) in patients with glyphosate surfactant herbicide (GSH) poisoning. METHODS: This study was performed between 2008 and 2021 and included 184 patients categorized into the AKI (n = 82) and non-AKI (n = 102) groups. The incidence, clinical characteristics, and severity of AKI were compared between the groups based on the Risk of renal dysfunction, Injury to the kidney, Failure or Loss of kidney function, and End-stage kidney disease (RIFLE) classification. RESULTS: The incidence of AKI was 44.5%, of which 25.0%, 6.5%, and 13.0% of patients were classified into the Risk, Injury, and Failure categories, respectively. Patients in the AKI group were older (63.3 ± 16.2 years vs. 57.4 ± 17.5 years, p = 0.02) than those in the non-AKI group. The length of hospitalization was longer (10.7 ± 12.1 days vs. 6.5 ± 8.1 days, p = 0.004) and hypotensive episodes occurred more frequently in the AKI group (45.1% vs. 8.8%, p < 0.001). Electrocardiographic (ECG) abnormalities on admission were more frequently observed in the AKI group than in the non-AKI group (80.5% vs. 47.1%, p < 0.001). Patients in the AKI group had poorer renal function (estimated glomerular filtration rate at the time of admission, 62.2 ± 22.9 mL/min/1.73 m(2) vs. 88.9 ± 26.1 mL/min/1.73 m(2), p < 0.001) on admission. The mortality rate was higher in the AKI group than in the non-AKI group (18.3% vs. 1.0%, p < 0.001). Multiple logistic regression analysis showed that hypotension and ECG abnormalities upon admission were significant predictors of AKI in patients with GSH poisoning. CONCLUSION: The presence of hypotension on admission may be a useful predictor of AKI in patients with GSH intoxication. The Korean Society of Nephrology 2023-05 2023-02-09 /pmc/articles/PMC10265214/ /pubmed/37098674 http://dx.doi.org/10.23876/j.krcp.22.051 Text en Copyright © 2023 The Korean Society of Nephrology https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial and No Derivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) which permits unrestricted non-commercial use, distribution of the material without any modifications, and reproduction in any medium, provided the original works properly cited. |
spellingShingle | Original Article Cho, A Young Oh, Ju Hwan Oh, Sung Sik Lee, Kwang Young Sun, In O Clinical characteristics of acute kidney injury in patients with glyphosate surfactant herbicide poisoning |
title | Clinical characteristics of acute kidney injury in patients with glyphosate surfactant herbicide poisoning |
title_full | Clinical characteristics of acute kidney injury in patients with glyphosate surfactant herbicide poisoning |
title_fullStr | Clinical characteristics of acute kidney injury in patients with glyphosate surfactant herbicide poisoning |
title_full_unstemmed | Clinical characteristics of acute kidney injury in patients with glyphosate surfactant herbicide poisoning |
title_short | Clinical characteristics of acute kidney injury in patients with glyphosate surfactant herbicide poisoning |
title_sort | clinical characteristics of acute kidney injury in patients with glyphosate surfactant herbicide poisoning |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265214/ https://www.ncbi.nlm.nih.gov/pubmed/37098674 http://dx.doi.org/10.23876/j.krcp.22.051 |
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