Cargando…

Successful treatment of severe Pneumocystis Jirovecii pneumonia in a diffuse large B-cell lymphoma patient after R-CHOP chemotherapy: A case report

R-CHOP chemotherapy has been established as the first-line standard treatment for elderly patients diagnosed with diffuse large B-cell lymphoma. However, an increased risk of Pneumocystis jirovecii pneumonia in diffuse large B-cell lymphoma patients after the rituximab-based chemotherapy has been re...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Yan, Li, Zhaolin, Ouyang, Lamei, Su, Yinqing, Wang, Canmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265330/
https://www.ncbi.nlm.nih.gov/pubmed/37325165
http://dx.doi.org/10.1177/2050313X231178050
_version_ 1785058510448361472
author Xu, Yan
Li, Zhaolin
Ouyang, Lamei
Su, Yinqing
Wang, Canmin
author_facet Xu, Yan
Li, Zhaolin
Ouyang, Lamei
Su, Yinqing
Wang, Canmin
author_sort Xu, Yan
collection PubMed
description R-CHOP chemotherapy has been established as the first-line standard treatment for elderly patients diagnosed with diffuse large B-cell lymphoma. However, an increased risk of Pneumocystis jirovecii pneumonia in diffuse large B-cell lymphoma patients after the rituximab-based chemotherapy has been reported. We describe a case who developed intermittent cough, fever and shortness of breath after five cycles of R-CHOP treatment for diffuse large B-cell lymphoma. A rapid deterioration in patient’s respiratory condition prompted us to adopt an aggressive anti- Pneumocystis jirovecii pneumonia strategy that combined the conventional trimethoprim/sulfamethoxazole and another two antimicrobials, caspofungin and clindamycin. This is the first report mentioning the successful treatment of severe Pneumocystis jirovecii pneumonia with a triple-drug regimen in a HIV-uninfected patient. The aim of our report is also to emphasize that early and correct diagnosis of Pneumocystis jirovecii pneumonia in immunocompromised HIV-uninfected patients is very important. Relevant oncologists should be alert to the risk of Pneumocystis jirovecii pneumonia in patients receiving R-CHOP chemotherapy.
format Online
Article
Text
id pubmed-10265330
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-102653302023-06-15 Successful treatment of severe Pneumocystis Jirovecii pneumonia in a diffuse large B-cell lymphoma patient after R-CHOP chemotherapy: A case report Xu, Yan Li, Zhaolin Ouyang, Lamei Su, Yinqing Wang, Canmin SAGE Open Med Case Rep Case Report R-CHOP chemotherapy has been established as the first-line standard treatment for elderly patients diagnosed with diffuse large B-cell lymphoma. However, an increased risk of Pneumocystis jirovecii pneumonia in diffuse large B-cell lymphoma patients after the rituximab-based chemotherapy has been reported. We describe a case who developed intermittent cough, fever and shortness of breath after five cycles of R-CHOP treatment for diffuse large B-cell lymphoma. A rapid deterioration in patient’s respiratory condition prompted us to adopt an aggressive anti- Pneumocystis jirovecii pneumonia strategy that combined the conventional trimethoprim/sulfamethoxazole and another two antimicrobials, caspofungin and clindamycin. This is the first report mentioning the successful treatment of severe Pneumocystis jirovecii pneumonia with a triple-drug regimen in a HIV-uninfected patient. The aim of our report is also to emphasize that early and correct diagnosis of Pneumocystis jirovecii pneumonia in immunocompromised HIV-uninfected patients is very important. Relevant oncologists should be alert to the risk of Pneumocystis jirovecii pneumonia in patients receiving R-CHOP chemotherapy. SAGE Publications 2023-06-02 /pmc/articles/PMC10265330/ /pubmed/37325165 http://dx.doi.org/10.1177/2050313X231178050 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Xu, Yan
Li, Zhaolin
Ouyang, Lamei
Su, Yinqing
Wang, Canmin
Successful treatment of severe Pneumocystis Jirovecii pneumonia in a diffuse large B-cell lymphoma patient after R-CHOP chemotherapy: A case report
title Successful treatment of severe Pneumocystis Jirovecii pneumonia in a diffuse large B-cell lymphoma patient after R-CHOP chemotherapy: A case report
title_full Successful treatment of severe Pneumocystis Jirovecii pneumonia in a diffuse large B-cell lymphoma patient after R-CHOP chemotherapy: A case report
title_fullStr Successful treatment of severe Pneumocystis Jirovecii pneumonia in a diffuse large B-cell lymphoma patient after R-CHOP chemotherapy: A case report
title_full_unstemmed Successful treatment of severe Pneumocystis Jirovecii pneumonia in a diffuse large B-cell lymphoma patient after R-CHOP chemotherapy: A case report
title_short Successful treatment of severe Pneumocystis Jirovecii pneumonia in a diffuse large B-cell lymphoma patient after R-CHOP chemotherapy: A case report
title_sort successful treatment of severe pneumocystis jirovecii pneumonia in a diffuse large b-cell lymphoma patient after r-chop chemotherapy: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265330/
https://www.ncbi.nlm.nih.gov/pubmed/37325165
http://dx.doi.org/10.1177/2050313X231178050
work_keys_str_mv AT xuyan successfultreatmentofseverepneumocystisjiroveciipneumoniainadiffuselargebcelllymphomapatientafterrchopchemotherapyacasereport
AT lizhaolin successfultreatmentofseverepneumocystisjiroveciipneumoniainadiffuselargebcelllymphomapatientafterrchopchemotherapyacasereport
AT ouyanglamei successfultreatmentofseverepneumocystisjiroveciipneumoniainadiffuselargebcelllymphomapatientafterrchopchemotherapyacasereport
AT suyinqing successfultreatmentofseverepneumocystisjiroveciipneumoniainadiffuselargebcelllymphomapatientafterrchopchemotherapyacasereport
AT wangcanmin successfultreatmentofseverepneumocystisjiroveciipneumoniainadiffuselargebcelllymphomapatientafterrchopchemotherapyacasereport