Subacute Horizontal Diplopia, Jaw Dystonia, and Laryngospasm

Jaw dystonia and laryngospasm in the context of subacute brainstem dysfunction have been described in a small number of diseases, including antineuronal nuclear antibody type 2 (ANNA-2, also known as anti-Ri) paraneoplastic neurologic syndrome. Severe episodes of laryngospasms causing cyanosis are p...

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Detalles Bibliográficos
Autores principales: Tisavipat, Nanthaya, Chang, Bryce K., Ali, Farwa, Pittock, Sean J., Kammeyer, Ryan, Declusin, Anthony, Cohn, Samuel J., Flanagan, Eoin P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Clinical/Scientific Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265402/
https://www.ncbi.nlm.nih.gov/pubmed/37311643
http://dx.doi.org/10.1212/NXI.0000000000200128
Descripción
Sumario:Jaw dystonia and laryngospasm in the context of subacute brainstem dysfunction have been described in a small number of diseases, including antineuronal nuclear antibody type 2 (ANNA-2, also known as anti-Ri) paraneoplastic neurologic syndrome. Severe episodes of laryngospasms causing cyanosis are potentially fatal. Jaw dystonia can also cause eating difficulty, resulting in severe weight loss and malnutrition. In this report, we highlight the multidisciplinary management of this syndrome associated with ANNA-2/anti-Ri paraneoplastic neurologic syndrome and discuss its pathogenesis.

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