Subacute Horizontal Diplopia, Jaw Dystonia, and Laryngospasm

Jaw dystonia and laryngospasm in the context of subacute brainstem dysfunction have been described in a small number of diseases, including antineuronal nuclear antibody type 2 (ANNA-2, also known as anti-Ri) paraneoplastic neurologic syndrome. Severe episodes of laryngospasms causing cyanosis are p...

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Autores principales: Tisavipat, Nanthaya, Chang, Bryce K., Ali, Farwa, Pittock, Sean J., Kammeyer, Ryan, Declusin, Anthony, Cohn, Samuel J., Flanagan, Eoin P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Clinical/Scientific Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265402/
https://www.ncbi.nlm.nih.gov/pubmed/37311643
http://dx.doi.org/10.1212/NXI.0000000000200128
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author Tisavipat, Nanthaya
Chang, Bryce K.
Ali, Farwa
Pittock, Sean J.
Kammeyer, Ryan
Declusin, Anthony
Cohn, Samuel J.
Flanagan, Eoin P.
author_facet Tisavipat, Nanthaya
Chang, Bryce K.
Ali, Farwa
Pittock, Sean J.
Kammeyer, Ryan
Declusin, Anthony
Cohn, Samuel J.
Flanagan, Eoin P.
author_sort Tisavipat, Nanthaya
collection PubMed
description Jaw dystonia and laryngospasm in the context of subacute brainstem dysfunction have been described in a small number of diseases, including antineuronal nuclear antibody type 2 (ANNA-2, also known as anti-Ri) paraneoplastic neurologic syndrome. Severe episodes of laryngospasms causing cyanosis are potentially fatal. Jaw dystonia can also cause eating difficulty, resulting in severe weight loss and malnutrition. In this report, we highlight the multidisciplinary management of this syndrome associated with ANNA-2/anti-Ri paraneoplastic neurologic syndrome and discuss its pathogenesis.
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spelling pubmed-102654022023-06-15 Subacute Horizontal Diplopia, Jaw Dystonia, and Laryngospasm Tisavipat, Nanthaya Chang, Bryce K. Ali, Farwa Pittock, Sean J. Kammeyer, Ryan Declusin, Anthony Cohn, Samuel J. Flanagan, Eoin P. Neurol Neuroimmunol Neuroinflamm Clinical/Scientific Note Jaw dystonia and laryngospasm in the context of subacute brainstem dysfunction have been described in a small number of diseases, including antineuronal nuclear antibody type 2 (ANNA-2, also known as anti-Ri) paraneoplastic neurologic syndrome. Severe episodes of laryngospasms causing cyanosis are potentially fatal. Jaw dystonia can also cause eating difficulty, resulting in severe weight loss and malnutrition. In this report, we highlight the multidisciplinary management of this syndrome associated with ANNA-2/anti-Ri paraneoplastic neurologic syndrome and discuss its pathogenesis. Lippincott Williams & Wilkins 2023-06-13 /pmc/articles/PMC10265402/ /pubmed/37311643 http://dx.doi.org/10.1212/NXI.0000000000200128 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Clinical/Scientific Note
Tisavipat, Nanthaya
Chang, Bryce K.
Ali, Farwa
Pittock, Sean J.
Kammeyer, Ryan
Declusin, Anthony
Cohn, Samuel J.
Flanagan, Eoin P.
Subacute Horizontal Diplopia, Jaw Dystonia, and Laryngospasm
title Subacute Horizontal Diplopia, Jaw Dystonia, and Laryngospasm
title_full Subacute Horizontal Diplopia, Jaw Dystonia, and Laryngospasm
title_fullStr Subacute Horizontal Diplopia, Jaw Dystonia, and Laryngospasm
title_full_unstemmed Subacute Horizontal Diplopia, Jaw Dystonia, and Laryngospasm
title_short Subacute Horizontal Diplopia, Jaw Dystonia, and Laryngospasm
title_sort subacute horizontal diplopia, jaw dystonia, and laryngospasm
topic Clinical/Scientific Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265402/
https://www.ncbi.nlm.nih.gov/pubmed/37311643
http://dx.doi.org/10.1212/NXI.0000000000200128
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