Biosynthesis of trialkyl-substituted aromatic polyketide NFAT-133 involves unusual P450 monooxygenase-mediating aromatization and a putative metallo-beta-lactamase fold hydrolase

The bacterial trialkyl-substituted aromatic polyketides are structurally featured with the unusual aromatic core in the middle of polyketide chain such as TM-123 (1), veramycin A (2), NFAT-133 (3) and benwamycin I (4), which were discovered from Streptomyces species and demonstrated with antidiabeti...

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Detalles Bibliográficos
Autores principales: Yang, Ming, Li, Wanlu, Zhou, Lin, Lin, Xiao, Zhang, Wenyu, Shen, Yaoyao, Deng, Hai, Lin, Hou-wen, Zhou, Yongjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265476/
https://www.ncbi.nlm.nih.gov/pubmed/37325182
http://dx.doi.org/10.1016/j.synbio.2023.05.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265476/
https://www.ncbi.nlm.nih.gov/pubmed/37325182
http://dx.doi.org/10.1016/j.synbio.2023.05.003

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