Cargando…
Non-coding RNA-mediated epigenetic alterations in Grave's ophthalmopathy: A scoping systematic review
BACKGROUND: It is becoming more and more apparent that Grave's Ophthalmopathy (GO) pathogenesis may be aided by epigenetic processes such as DNA methylation modifications, histone tail covalent modifications, and non-coding RNA (ncRNA)-based epigenetic processes. In the present study, we aimed...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
KeAi Publishing
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265490/ https://www.ncbi.nlm.nih.gov/pubmed/37324526 http://dx.doi.org/10.1016/j.ncrna.2023.04.001 |
_version_ | 1785058543604334592 |
---|---|
author | Shahraki, Kourosh Pak, Vida Ilkhani Najafi, Amin Shahraki, Kianoush Boroumand, Paria Ghasemi Sheervalilou, Roghayeh |
author_facet | Shahraki, Kourosh Pak, Vida Ilkhani Najafi, Amin Shahraki, Kianoush Boroumand, Paria Ghasemi Sheervalilou, Roghayeh |
author_sort | Shahraki, Kourosh |
collection | PubMed |
description | BACKGROUND: It is becoming more and more apparent that Grave's Ophthalmopathy (GO) pathogenesis may be aided by epigenetic processes such as DNA methylation modifications, histone tail covalent modifications, and non-coding RNA (ncRNA)-based epigenetic processes. In the present study, we aimed to focus more on the miRNAs rather than lncRNAs due to lack of investigations on these non-coding RNAs and their role in GO's pathogenesis. METHODS: A six-stage methodology framework and the PRISMA recommendation were used to conduct this scoping review. A comprehensive search was conducted across seven databases to discover relevant papers published until February 2022. The data extraction separately, and quantitative and qualitative analyses were conducted. RESULTS: A total of 20 articles were found to meet inclusion criteria. According to the results, ncRNA were involved in the regulation of inflammation (miR-146a, LPAL2/miR-1287–5p axis, LINC01820:13/hsa miR-27b-3p axis, and ENST00000499452/hsa-miR-27a-3p axis), regulation of T cell functions (miR-146a/miR-183/miR-96), regulation of glycosaminoglycan aggregation and fibrosis (miR-146a/miR-21), glucocorticoid sensitivity (miR-224–5p), lipid accumulation and adipogenesis (miR-27a/miR-27b/miR-130a), oxidative stress and angiogenesis (miR-199a), and orbital fibroblast proliferation (miR-21/miR-146a/miR-155). Eleven miRNAs (miR-146a/miR-224–5p/miR-Let7d-5p/miR-96–5p/miR-301a-3p/miR-21–5p) were also indicated to have the capacity to be used as biomarkers. CONCLUSIONS: Regardless of the fact that there is significant documentation of ncRNA-mediated epigenetic dysfunction in GO, additional study is needed to thoroughly comprehend the epigenetic connections concerned in disease pathogenesis, paving the way for novel diagnostic and prognostic tools for epigenetic therapies among the patients. |
format | Online Article Text |
id | pubmed-10265490 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | KeAi Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-102654902023-06-15 Non-coding RNA-mediated epigenetic alterations in Grave's ophthalmopathy: A scoping systematic review Shahraki, Kourosh Pak, Vida Ilkhani Najafi, Amin Shahraki, Kianoush Boroumand, Paria Ghasemi Sheervalilou, Roghayeh Noncoding RNA Res Article BACKGROUND: It is becoming more and more apparent that Grave's Ophthalmopathy (GO) pathogenesis may be aided by epigenetic processes such as DNA methylation modifications, histone tail covalent modifications, and non-coding RNA (ncRNA)-based epigenetic processes. In the present study, we aimed to focus more on the miRNAs rather than lncRNAs due to lack of investigations on these non-coding RNAs and their role in GO's pathogenesis. METHODS: A six-stage methodology framework and the PRISMA recommendation were used to conduct this scoping review. A comprehensive search was conducted across seven databases to discover relevant papers published until February 2022. The data extraction separately, and quantitative and qualitative analyses were conducted. RESULTS: A total of 20 articles were found to meet inclusion criteria. According to the results, ncRNA were involved in the regulation of inflammation (miR-146a, LPAL2/miR-1287–5p axis, LINC01820:13/hsa miR-27b-3p axis, and ENST00000499452/hsa-miR-27a-3p axis), regulation of T cell functions (miR-146a/miR-183/miR-96), regulation of glycosaminoglycan aggregation and fibrosis (miR-146a/miR-21), glucocorticoid sensitivity (miR-224–5p), lipid accumulation and adipogenesis (miR-27a/miR-27b/miR-130a), oxidative stress and angiogenesis (miR-199a), and orbital fibroblast proliferation (miR-21/miR-146a/miR-155). Eleven miRNAs (miR-146a/miR-224–5p/miR-Let7d-5p/miR-96–5p/miR-301a-3p/miR-21–5p) were also indicated to have the capacity to be used as biomarkers. CONCLUSIONS: Regardless of the fact that there is significant documentation of ncRNA-mediated epigenetic dysfunction in GO, additional study is needed to thoroughly comprehend the epigenetic connections concerned in disease pathogenesis, paving the way for novel diagnostic and prognostic tools for epigenetic therapies among the patients. KeAi Publishing 2023-05-16 /pmc/articles/PMC10265490/ /pubmed/37324526 http://dx.doi.org/10.1016/j.ncrna.2023.04.001 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Shahraki, Kourosh Pak, Vida Ilkhani Najafi, Amin Shahraki, Kianoush Boroumand, Paria Ghasemi Sheervalilou, Roghayeh Non-coding RNA-mediated epigenetic alterations in Grave's ophthalmopathy: A scoping systematic review |
title | Non-coding RNA-mediated epigenetic alterations in Grave's ophthalmopathy: A scoping systematic review |
title_full | Non-coding RNA-mediated epigenetic alterations in Grave's ophthalmopathy: A scoping systematic review |
title_fullStr | Non-coding RNA-mediated epigenetic alterations in Grave's ophthalmopathy: A scoping systematic review |
title_full_unstemmed | Non-coding RNA-mediated epigenetic alterations in Grave's ophthalmopathy: A scoping systematic review |
title_short | Non-coding RNA-mediated epigenetic alterations in Grave's ophthalmopathy: A scoping systematic review |
title_sort | non-coding rna-mediated epigenetic alterations in grave's ophthalmopathy: a scoping systematic review |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265490/ https://www.ncbi.nlm.nih.gov/pubmed/37324526 http://dx.doi.org/10.1016/j.ncrna.2023.04.001 |
work_keys_str_mv | AT shahrakikourosh noncodingrnamediatedepigeneticalterationsingravesophthalmopathyascopingsystematicreview AT pakvidailkhani noncodingrnamediatedepigeneticalterationsingravesophthalmopathyascopingsystematicreview AT najafiamin noncodingrnamediatedepigeneticalterationsingravesophthalmopathyascopingsystematicreview AT shahrakikianoush noncodingrnamediatedepigeneticalterationsingravesophthalmopathyascopingsystematicreview AT boroumandpariaghasemi noncodingrnamediatedepigeneticalterationsingravesophthalmopathyascopingsystematicreview AT sheervalilouroghayeh noncodingrnamediatedepigeneticalterationsingravesophthalmopathyascopingsystematicreview |