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Non-coding RNA-mediated epigenetic alterations in Grave's ophthalmopathy: A scoping systematic review

BACKGROUND: It is becoming more and more apparent that Grave's Ophthalmopathy (GO) pathogenesis may be aided by epigenetic processes such as DNA methylation modifications, histone tail covalent modifications, and non-coding RNA (ncRNA)-based epigenetic processes. In the present study, we aimed...

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Autores principales: Shahraki, Kourosh, Pak, Vida Ilkhani, Najafi, Amin, Shahraki, Kianoush, Boroumand, Paria Ghasemi, Sheervalilou, Roghayeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265490/
https://www.ncbi.nlm.nih.gov/pubmed/37324526
http://dx.doi.org/10.1016/j.ncrna.2023.04.001
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author Shahraki, Kourosh
Pak, Vida Ilkhani
Najafi, Amin
Shahraki, Kianoush
Boroumand, Paria Ghasemi
Sheervalilou, Roghayeh
author_facet Shahraki, Kourosh
Pak, Vida Ilkhani
Najafi, Amin
Shahraki, Kianoush
Boroumand, Paria Ghasemi
Sheervalilou, Roghayeh
author_sort Shahraki, Kourosh
collection PubMed
description BACKGROUND: It is becoming more and more apparent that Grave's Ophthalmopathy (GO) pathogenesis may be aided by epigenetic processes such as DNA methylation modifications, histone tail covalent modifications, and non-coding RNA (ncRNA)-based epigenetic processes. In the present study, we aimed to focus more on the miRNAs rather than lncRNAs due to lack of investigations on these non-coding RNAs and their role in GO's pathogenesis. METHODS: A six-stage methodology framework and the PRISMA recommendation were used to conduct this scoping review. A comprehensive search was conducted across seven databases to discover relevant papers published until February 2022. The data extraction separately, and quantitative and qualitative analyses were conducted. RESULTS: A total of 20 articles were found to meet inclusion criteria. According to the results, ncRNA were involved in the regulation of inflammation (miR-146a, LPAL2/miR-1287–5p axis, LINC01820:13/hsa miR-27b-3p axis, and ENST00000499452/hsa-miR-27a-3p axis), regulation of T cell functions (miR-146a/miR-183/miR-96), regulation of glycosaminoglycan aggregation and fibrosis (miR-146a/miR-21), glucocorticoid sensitivity (miR-224–5p), lipid accumulation and adipogenesis (miR-27a/miR-27b/miR-130a), oxidative stress and angiogenesis (miR-199a), and orbital fibroblast proliferation (miR-21/miR-146a/miR-155). Eleven miRNAs (miR-146a/miR-224–5p/miR-Let7d-5p/miR-96–5p/miR-301a-3p/miR-21–5p) were also indicated to have the capacity to be used as biomarkers. CONCLUSIONS: Regardless of the fact that there is significant documentation of ncRNA-mediated epigenetic dysfunction in GO, additional study is needed to thoroughly comprehend the epigenetic connections concerned in disease pathogenesis, paving the way for novel diagnostic and prognostic tools for epigenetic therapies among the patients.
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spelling pubmed-102654902023-06-15 Non-coding RNA-mediated epigenetic alterations in Grave's ophthalmopathy: A scoping systematic review Shahraki, Kourosh Pak, Vida Ilkhani Najafi, Amin Shahraki, Kianoush Boroumand, Paria Ghasemi Sheervalilou, Roghayeh Noncoding RNA Res Article BACKGROUND: It is becoming more and more apparent that Grave's Ophthalmopathy (GO) pathogenesis may be aided by epigenetic processes such as DNA methylation modifications, histone tail covalent modifications, and non-coding RNA (ncRNA)-based epigenetic processes. In the present study, we aimed to focus more on the miRNAs rather than lncRNAs due to lack of investigations on these non-coding RNAs and their role in GO's pathogenesis. METHODS: A six-stage methodology framework and the PRISMA recommendation were used to conduct this scoping review. A comprehensive search was conducted across seven databases to discover relevant papers published until February 2022. The data extraction separately, and quantitative and qualitative analyses were conducted. RESULTS: A total of 20 articles were found to meet inclusion criteria. According to the results, ncRNA were involved in the regulation of inflammation (miR-146a, LPAL2/miR-1287–5p axis, LINC01820:13/hsa miR-27b-3p axis, and ENST00000499452/hsa-miR-27a-3p axis), regulation of T cell functions (miR-146a/miR-183/miR-96), regulation of glycosaminoglycan aggregation and fibrosis (miR-146a/miR-21), glucocorticoid sensitivity (miR-224–5p), lipid accumulation and adipogenesis (miR-27a/miR-27b/miR-130a), oxidative stress and angiogenesis (miR-199a), and orbital fibroblast proliferation (miR-21/miR-146a/miR-155). Eleven miRNAs (miR-146a/miR-224–5p/miR-Let7d-5p/miR-96–5p/miR-301a-3p/miR-21–5p) were also indicated to have the capacity to be used as biomarkers. CONCLUSIONS: Regardless of the fact that there is significant documentation of ncRNA-mediated epigenetic dysfunction in GO, additional study is needed to thoroughly comprehend the epigenetic connections concerned in disease pathogenesis, paving the way for novel diagnostic and prognostic tools for epigenetic therapies among the patients. KeAi Publishing 2023-05-16 /pmc/articles/PMC10265490/ /pubmed/37324526 http://dx.doi.org/10.1016/j.ncrna.2023.04.001 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Shahraki, Kourosh
Pak, Vida Ilkhani
Najafi, Amin
Shahraki, Kianoush
Boroumand, Paria Ghasemi
Sheervalilou, Roghayeh
Non-coding RNA-mediated epigenetic alterations in Grave's ophthalmopathy: A scoping systematic review
title Non-coding RNA-mediated epigenetic alterations in Grave's ophthalmopathy: A scoping systematic review
title_full Non-coding RNA-mediated epigenetic alterations in Grave's ophthalmopathy: A scoping systematic review
title_fullStr Non-coding RNA-mediated epigenetic alterations in Grave's ophthalmopathy: A scoping systematic review
title_full_unstemmed Non-coding RNA-mediated epigenetic alterations in Grave's ophthalmopathy: A scoping systematic review
title_short Non-coding RNA-mediated epigenetic alterations in Grave's ophthalmopathy: A scoping systematic review
title_sort non-coding rna-mediated epigenetic alterations in grave's ophthalmopathy: a scoping systematic review
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265490/
https://www.ncbi.nlm.nih.gov/pubmed/37324526
http://dx.doi.org/10.1016/j.ncrna.2023.04.001
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