Cargando…

Case Report: Prurigo nodularis-like linear IgA/IgG bullous dermatosis: a case report and literature review

Linear IgA/IgG bullous dermatosis (LAGBD) is a rare autoimmune subepidermal bullous disorder characterized by linear deposition of concurrent IgA and IgG autoantibodies along the basement membrane zone (BMZ). The clinical features of LAGBD can be diverse, including tense blisters, erosions, erythema...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Yuxi, Zhou, Xingli, Feng, Xun, Xia, Dengmei, Qian, Hua, Liu, Hongjie, Li, Xiaoguang, Li, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265503/
https://www.ncbi.nlm.nih.gov/pubmed/37325615
http://dx.doi.org/10.3389/fimmu.2023.1201163
_version_ 1785058545975164928
author Zhou, Yuxi
Zhou, Xingli
Feng, Xun
Xia, Dengmei
Qian, Hua
Liu, Hongjie
Li, Xiaoguang
Li, Wei
author_facet Zhou, Yuxi
Zhou, Xingli
Feng, Xun
Xia, Dengmei
Qian, Hua
Liu, Hongjie
Li, Xiaoguang
Li, Wei
author_sort Zhou, Yuxi
collection PubMed
description Linear IgA/IgG bullous dermatosis (LAGBD) is a rare autoimmune subepidermal bullous disorder characterized by linear deposition of concurrent IgA and IgG autoantibodies along the basement membrane zone (BMZ). The clinical features of LAGBD can be diverse, including tense blisters, erosions, erythema, crusting and mucosa involvement, while papules or nodules are generally absent. In this study, we present a unique case of LAGBD, which showed prurigo nodularis-like clinical appearance on physical examination, linear deposition of IgG and C3 along the basement membrane zone (BMZ) in direct immunofluorescence (DIF), IgA autoantibodies against the 97-kDa and 120-kDa of BP180 and IgG autoantibodies against the 97-kDa of BP180 by immunoblotting (IB), while BP180 NC16a domain, BP230, and laminin 332 were negative by enzyme-linked immunosorbent assay (ELISA). After administration of minocycline, the skin lesions improved. We performed a literature review of LAGBD cases with heterogeneous autoantibodies and found clinical presentations of most cases resemble bullous pemphigoid (BP) and linear IgA bullous disease (LABD), which is consistent with previous reported findings. We aim to increase our understanding of this disorder and to enhance the importance of applying immunoblot analyses and other serological detection tools in clinic for precise diagnosis as well as accurate treatment strategy of various autoimmune bullous dermatoses.
format Online
Article
Text
id pubmed-10265503
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-102655032023-06-15 Case Report: Prurigo nodularis-like linear IgA/IgG bullous dermatosis: a case report and literature review Zhou, Yuxi Zhou, Xingli Feng, Xun Xia, Dengmei Qian, Hua Liu, Hongjie Li, Xiaoguang Li, Wei Front Immunol Immunology Linear IgA/IgG bullous dermatosis (LAGBD) is a rare autoimmune subepidermal bullous disorder characterized by linear deposition of concurrent IgA and IgG autoantibodies along the basement membrane zone (BMZ). The clinical features of LAGBD can be diverse, including tense blisters, erosions, erythema, crusting and mucosa involvement, while papules or nodules are generally absent. In this study, we present a unique case of LAGBD, which showed prurigo nodularis-like clinical appearance on physical examination, linear deposition of IgG and C3 along the basement membrane zone (BMZ) in direct immunofluorescence (DIF), IgA autoantibodies against the 97-kDa and 120-kDa of BP180 and IgG autoantibodies against the 97-kDa of BP180 by immunoblotting (IB), while BP180 NC16a domain, BP230, and laminin 332 were negative by enzyme-linked immunosorbent assay (ELISA). After administration of minocycline, the skin lesions improved. We performed a literature review of LAGBD cases with heterogeneous autoantibodies and found clinical presentations of most cases resemble bullous pemphigoid (BP) and linear IgA bullous disease (LABD), which is consistent with previous reported findings. We aim to increase our understanding of this disorder and to enhance the importance of applying immunoblot analyses and other serological detection tools in clinic for precise diagnosis as well as accurate treatment strategy of various autoimmune bullous dermatoses. Frontiers Media S.A. 2023-05-30 /pmc/articles/PMC10265503/ /pubmed/37325615 http://dx.doi.org/10.3389/fimmu.2023.1201163 Text en Copyright © 2023 Zhou, Zhou, Feng, Xia, Qian, Liu, Li and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhou, Yuxi
Zhou, Xingli
Feng, Xun
Xia, Dengmei
Qian, Hua
Liu, Hongjie
Li, Xiaoguang
Li, Wei
Case Report: Prurigo nodularis-like linear IgA/IgG bullous dermatosis: a case report and literature review
title Case Report: Prurigo nodularis-like linear IgA/IgG bullous dermatosis: a case report and literature review
title_full Case Report: Prurigo nodularis-like linear IgA/IgG bullous dermatosis: a case report and literature review
title_fullStr Case Report: Prurigo nodularis-like linear IgA/IgG bullous dermatosis: a case report and literature review
title_full_unstemmed Case Report: Prurigo nodularis-like linear IgA/IgG bullous dermatosis: a case report and literature review
title_short Case Report: Prurigo nodularis-like linear IgA/IgG bullous dermatosis: a case report and literature review
title_sort case report: prurigo nodularis-like linear iga/igg bullous dermatosis: a case report and literature review
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265503/
https://www.ncbi.nlm.nih.gov/pubmed/37325615
http://dx.doi.org/10.3389/fimmu.2023.1201163
work_keys_str_mv AT zhouyuxi casereportprurigonodularislikelinearigaiggbullousdermatosisacasereportandliteraturereview
AT zhouxingli casereportprurigonodularislikelinearigaiggbullousdermatosisacasereportandliteraturereview
AT fengxun casereportprurigonodularislikelinearigaiggbullousdermatosisacasereportandliteraturereview
AT xiadengmei casereportprurigonodularislikelinearigaiggbullousdermatosisacasereportandliteraturereview
AT qianhua casereportprurigonodularislikelinearigaiggbullousdermatosisacasereportandliteraturereview
AT liuhongjie casereportprurigonodularislikelinearigaiggbullousdermatosisacasereportandliteraturereview
AT lixiaoguang casereportprurigonodularislikelinearigaiggbullousdermatosisacasereportandliteraturereview
AT liwei casereportprurigonodularislikelinearigaiggbullousdermatosisacasereportandliteraturereview