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The burden associated with generalized pustular psoriasis: A Canadian population-based study of inpatient care, emergency departments, and hospital- or community-based outpatient clinics
BACKGROUND: Not much is known about the burden of generalized pustular psoriasis (GPP). OBJECTIVES: To document the burden of GPP in Canada and to compare it with psoriasis vulgaris (PV). METHODS: National data were used to identify Canadian adult patients with GPP or PV hospitalized or visiting an...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265504/ https://www.ncbi.nlm.nih.gov/pubmed/37325044 http://dx.doi.org/10.1016/j.jdin.2023.03.012 |
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author | Tarride, Jean-Eric Prajapati, Vimal H. Lynde, Charles Blackhouse, Gord |
author_facet | Tarride, Jean-Eric Prajapati, Vimal H. Lynde, Charles Blackhouse, Gord |
author_sort | Tarride, Jean-Eric |
collection | PubMed |
description | BACKGROUND: Not much is known about the burden of generalized pustular psoriasis (GPP). OBJECTIVES: To document the burden of GPP in Canada and to compare it with psoriasis vulgaris (PV). METHODS: National data were used to identify Canadian adult patients with GPP or PV hospitalized or visiting an emergency department (ED) or hospital-/community-based clinic between April 1, 2007, and March 31, 2020. Analyses of 10-year prevalence and 3-year incidence were conducted. Costs were determined when the most responsible diagnosis (MRD) was GPP or PV (MRD costs) and for all reasons (all-cause costs). RESULTS: In the prevalence analysis, 10-year mean (SD) MRD costs were $2393 ($11,410) for patients with GPP and $222 ($1828) for those with PV (P < .01). In the incidence analysis, patients with GPP had higher 3-year mean (SD) MRD costs ($3477 [$14,979] vs $503 [$2267] for PV; P < .01). Higher all-cause costs were also associated with patients with GPP. Inpatient/ED mortality was higher in the GPP group in our 10-year prevalence (9.2% for patients with GPP vs 7.3% for those with PV; P = .01) and 3-year incidence (5.2% for patients with GPP and 2.1% for those with PV; P = .03) analyses. LIMITATIONS: Physician and prescription drug data were not available. CONCLUSION: Patients with GPP incurred higher costs and mortality than patients with PV. |
format | Online Article Text |
id | pubmed-10265504 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-102655042023-06-15 The burden associated with generalized pustular psoriasis: A Canadian population-based study of inpatient care, emergency departments, and hospital- or community-based outpatient clinics Tarride, Jean-Eric Prajapati, Vimal H. Lynde, Charles Blackhouse, Gord JAAD Int Original Article BACKGROUND: Not much is known about the burden of generalized pustular psoriasis (GPP). OBJECTIVES: To document the burden of GPP in Canada and to compare it with psoriasis vulgaris (PV). METHODS: National data were used to identify Canadian adult patients with GPP or PV hospitalized or visiting an emergency department (ED) or hospital-/community-based clinic between April 1, 2007, and March 31, 2020. Analyses of 10-year prevalence and 3-year incidence were conducted. Costs were determined when the most responsible diagnosis (MRD) was GPP or PV (MRD costs) and for all reasons (all-cause costs). RESULTS: In the prevalence analysis, 10-year mean (SD) MRD costs were $2393 ($11,410) for patients with GPP and $222 ($1828) for those with PV (P < .01). In the incidence analysis, patients with GPP had higher 3-year mean (SD) MRD costs ($3477 [$14,979] vs $503 [$2267] for PV; P < .01). Higher all-cause costs were also associated with patients with GPP. Inpatient/ED mortality was higher in the GPP group in our 10-year prevalence (9.2% for patients with GPP vs 7.3% for those with PV; P = .01) and 3-year incidence (5.2% for patients with GPP and 2.1% for those with PV; P = .03) analyses. LIMITATIONS: Physician and prescription drug data were not available. CONCLUSION: Patients with GPP incurred higher costs and mortality than patients with PV. Elsevier 2023-04-14 /pmc/articles/PMC10265504/ /pubmed/37325044 http://dx.doi.org/10.1016/j.jdin.2023.03.012 Text en © 2023 by the American Academy of Dermatology, Inc. Published by Elsevier Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Original Article Tarride, Jean-Eric Prajapati, Vimal H. Lynde, Charles Blackhouse, Gord The burden associated with generalized pustular psoriasis: A Canadian population-based study of inpatient care, emergency departments, and hospital- or community-based outpatient clinics |
title | The burden associated with generalized pustular psoriasis: A Canadian population-based study of inpatient care, emergency departments, and hospital- or community-based outpatient clinics |
title_full | The burden associated with generalized pustular psoriasis: A Canadian population-based study of inpatient care, emergency departments, and hospital- or community-based outpatient clinics |
title_fullStr | The burden associated with generalized pustular psoriasis: A Canadian population-based study of inpatient care, emergency departments, and hospital- or community-based outpatient clinics |
title_full_unstemmed | The burden associated with generalized pustular psoriasis: A Canadian population-based study of inpatient care, emergency departments, and hospital- or community-based outpatient clinics |
title_short | The burden associated with generalized pustular psoriasis: A Canadian population-based study of inpatient care, emergency departments, and hospital- or community-based outpatient clinics |
title_sort | burden associated with generalized pustular psoriasis: a canadian population-based study of inpatient care, emergency departments, and hospital- or community-based outpatient clinics |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265504/ https://www.ncbi.nlm.nih.gov/pubmed/37325044 http://dx.doi.org/10.1016/j.jdin.2023.03.012 |
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