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Whole-genome CRISPR screen identifies RAVER1 as a key regulator of RIPK1-mediated inflammatory cell death, PANoptosis

Transforming growth factor-β-activated kinase 1 (TAK1) is a central regulator of innate immunity, cell death, inflammation, and cellular homeostasis. Therefore, many pathogens carry TAK1 inhibitors (TAK1i). As a host strategy to counteract this, inhibition or deletion of TAK1 induces spontaneous inf...

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Detalles Bibliográficos
Autores principales:	Malireddi, R.K. Subbarao, Bynigeri, Ratnakar R., Mall, Raghvendra, Nadendla, Eswar Kumar, Connelly, Jon P., Pruett-Miller, Shondra M., Kanneganti, Thirumala-Devi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265528/ https://www.ncbi.nlm.nih.gov/pubmed/37324531 http://dx.doi.org/10.1016/j.isci.2023.106938

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