Restored autophagy is protective against PAK3-induced cardiac dysfunction

Despite the development of clinical treatments, heart failure remains the leading cause of mortality. We observed that p21-activated kinase 3 (PAK3) was augmented in failing human and mouse hearts. Furthermore, mice with cardiac-specific PAK3 overexpression exhibited exacerbated pathological remodel...

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Detalles Bibliográficos
Autores principales: Ruiz-Velasco, Andrea, Raja, Rida, Chen, Xinyi, Ganenthiran, Haresh, Kaur, Namrita, Alatawi, Nasser hawimel o, Miller, Jessica M., Abouleisa, Riham R.E., Ou, Qinghui, Zhao, Xiangjun, Fonseka, Oveena, Wang, Xin, Hille, Susanne S., Frey, Norbert, Wang, Tao, Mohamed, Tamer M.A., Müller, Oliver J., Cartwright, Elizabeth J., Liu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265534/
https://www.ncbi.nlm.nih.gov/pubmed/37324527
http://dx.doi.org/10.1016/j.isci.2023.106970

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