Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon

Excessive inflammation-associated coagulation is a feature of infectious diseases, occurring in such conditions as bacterial sepsis and COVID-19. It can lead to disseminated intravascular coagulation, one of the leading causes of mortality worldwide. Recently, type I interferon (IFN) signaling has b...

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Detalles Bibliográficos
Autores principales: Ryan, Tristram A. J., Hooftman, Alexander, Rehill, Aisling M., Johansen, Matt D., Brien, Eóin C. O’, Toller-Kawahisa, Juliana E., Wilk, Mieszko M., Day, Emily A., Weiss, Hauke J., Sarvari, Pourya, Vozza, Emilio G., Schramm, Fabian, Peace, Christian G., Zotta, Alessia, Miemczyk, Stefan, Nalkurthi, Christina, Hansbro, Nicole G., McManus, Gavin, O’Doherty, Laura, Gargan, Siobhan, Long, Aideen, Dunne, Jean, Cheallaigh, Clíona Ní, Conlon, Niall, Carty, Michael, Fallon, Padraic G., Mills, Kingston H. G., Creagh, Emma M., Donnell, James S. O’, Hertzog, Paul J., Hansbro, Philip M., McLoughlin, Rachel M., Wygrecka, Małgorzata, Preston, Roger J. S., Zasłona, Zbigniew, O’Neill, Luke A. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265568/
https://www.ncbi.nlm.nih.gov/pubmed/37316487
http://dx.doi.org/10.1038/s41467-023-39174-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265568/
https://www.ncbi.nlm.nih.gov/pubmed/37316487
http://dx.doi.org/10.1038/s41467-023-39174-1

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