Leveraging CD16 fusion receptors to remodel the immune response for enhancing anti-tumor immunotherapy in iPSC-derived NK cells

BACKGROUND: The cytotoxicity of NK cells is largely dependent on IgG Fc receptor CD16a, which mediates antibody-dependent cell-mediated cytotoxicity (ADCC). The high-affinity and non-cleavable CD16 (hnCD16) is developed and demonstrated a multi-tumor killing potential. However, the hnCD16 receptor a...

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Detalles Bibliográficos
Autores principales: Meng, Fanyi, Zhang, Siqi, Xie, Juan, Zhou, Yuan, Wu, Qingling, Lu, Binyan, Zhou, Shixin, Zhao, Xiangyu, Li, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265820/
https://www.ncbi.nlm.nih.gov/pubmed/37316891
http://dx.doi.org/10.1186/s13045-023-01455-z

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