Analysis of RAS and drug induced homo- and heterodimerization of RAF and KSR1 proteins in living cells using split Nanoluc luciferase

The dimerization of RAF kinases represents a key event in their activation cycle and in RAS/ERK pathway activation. Genetic, biochemical and structural approaches provided key insights into this process defining RAF signaling output and the clinical efficacy of RAF inhibitors (RAFi). However, method...

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Detalles Bibliográficos
Autores principales: Rohrer, Lino, Spohr, Corinna, Beha, Carina, Griffin, Ricarda, Braun, Sandra, Halbach, Sebastian, Brummer, Tilman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265822/
https://www.ncbi.nlm.nih.gov/pubmed/37316874
http://dx.doi.org/10.1186/s12964-023-01146-9

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