Endothelin-1 induces connective tissue growth factor expression in human lung fibroblasts by disrupting HDAC2/Sin3A/MeCP2 corepressor complex

BACKGROUND: Reduction of histone deacetylase (HDAC) 2 expression and activity may contribute to amplified inflammation in patients with severe asthma. Connective tissue growth factor (CTGF) is a key mediator of airway fibrosis in severe asthma. However, the role of the HDAC2/Sin3A/methyl-CpG-binding...

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Detalles Bibliográficos
Autores principales: Hua, Hung-Sheng, Wen, Heng-Ching, Lee, Hong-Sheng, Weng, Chih-Ming, Yuliani, Fara Silvia, Kuo, Han-Pin, Chen, Bing-Chang, Lin, Chien-Huang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265878/
https://www.ncbi.nlm.nih.gov/pubmed/37312162
http://dx.doi.org/10.1186/s12929-023-00931-5

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