Phosphorylation of α-synuclein at T64 results in distinct oligomers and exerts toxicity in models of Parkinson’s disease

α-Synuclein accumulates in Lewy bodies, and this accumulation is a pathological hallmark of Parkinson’s disease (PD). Previous studies have indicated a causal role of α-synuclein in the pathogenesis of PD. However, the molecular and cellular mechanisms of α-synuclein toxicity remain elusive. Here, w...

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Detalles Bibliográficos
Autores principales: Matsui, Hideaki, Ito, Shinji, Matsui, Hideki, Ito, Junko, Gabdulkhaev, Ramil, Hirose, Mika, Yamanaka, Tomoyuki, Koyama, Akihide, Kato, Taisuke, Tanaka, Maiko, Uemura, Norihito, Matsui, Noriko, Hirokawa, Sachiko, Yoshihama, Maki, Shimozawa, Aki, Kubo, Shin-ichiro, Iwasaki, Kenji, Hasegawa, Masato, Takahashi, Ryosuke, Hirai, Keisuke, Kakita, Akiyoshi, Onodera, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266017/
https://www.ncbi.nlm.nih.gov/pubmed/37252975
http://dx.doi.org/10.1073/pnas.2214652120

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