Proline hydroxylation of CREB-regulated transcriptional coactivator 2 controls hepatic glucose metabolism

Prolyl hydroxylase domain (PHD) enzymes change HIF activity according to oxygen signal; whether it is regulated by other physiological conditions remains largely unknown. Here, we report that PHD3 is induced by fasting and regulates hepatic gluconeogenesis through interaction and hydroxylation of CR...

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Detalles Bibliográficos
Autores principales: Xue, Yaqian, Cui, Aoyuan, Wei, Shuang, Ma, Fengguang, Liu, Zhengshuai, Fang, Xia, Huo, Shaofeng, Sun, Xiaoyang, Li, Wenjing, Hu, Zhimin, Liu, Yuxiao, Cai, Genxiang, Su, Weitong, Zhao, Jiuxiang, Yan, Xi, Gao, Chenlin, Wen, Jian, Zhang, Haibing, Li, Hong, Liu, Yi, Lin, Xu, Xu, Yong, Fu, Wenguang, Fang, Jing, Li, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266032/
https://www.ncbi.nlm.nih.gov/pubmed/37252972
http://dx.doi.org/10.1073/pnas.2219419120

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