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WWOX Polymorphisms as Predictors of the Biochemical Recurrence of Localized Prostate Cancer after Radical Prostatectomy

The downregulation of WW domain-containing oxidoreductase (WWOX), a tumor suppressor gene, is associated with the tumorigenesis and poor prognosis of various cancers. In this study, we investigated the associations between the polymorphisms of WWOX, clinicopathologic features of prostate cancer (PCa...

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Autores principales: Lin, Chia-Yen, Wang, Chun-Li, Wang, Shian-Shiang, Yang, Cheng-Kuang, Li, Jian-Ri, Chen, Chuan-Shu, Hung, Sheng-Chun, Chiu, Kun-Yuan, Cheng, Chen-Li, Ou, Yen-Chuan, Yang, Shun-Fa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266044/
https://www.ncbi.nlm.nih.gov/pubmed/37324196
http://dx.doi.org/10.7150/ijms.84364
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author Lin, Chia-Yen
Wang, Chun-Li
Wang, Shian-Shiang
Yang, Cheng-Kuang
Li, Jian-Ri
Chen, Chuan-Shu
Hung, Sheng-Chun
Chiu, Kun-Yuan
Cheng, Chen-Li
Ou, Yen-Chuan
Yang, Shun-Fa
author_facet Lin, Chia-Yen
Wang, Chun-Li
Wang, Shian-Shiang
Yang, Cheng-Kuang
Li, Jian-Ri
Chen, Chuan-Shu
Hung, Sheng-Chun
Chiu, Kun-Yuan
Cheng, Chen-Li
Ou, Yen-Chuan
Yang, Shun-Fa
author_sort Lin, Chia-Yen
collection PubMed
description The downregulation of WW domain-containing oxidoreductase (WWOX), a tumor suppressor gene, is associated with the tumorigenesis and poor prognosis of various cancers. In this study, we investigated the associations between the polymorphisms of WWOX, clinicopathologic features of prostate cancer (PCa), and risk of postoperative biochemical recurrence (BCR). We evaluated the effects of five single-nucleotide polymorphisms (SNPs) of WWOX on the clinicopathologic features of 578 patients with PCa. The risk of postoperative BCR was 2.053-fold higher in patients carrying at least one “A” allele in WWOX rs12918952 than in those with homozygous G/G. Furthermore, patients with at least one polymorphic “T” allele in WWOX rs11545028 had an elevated (1.504-fold) risk of PCa with seminal vesicle invasion. In patients with postoperative BCR, the risks of an advanced Gleason grade and clinical metastasis were 3.317- and 5.259-fold higher in patients carrying at least one “G” allele in WWOX rs3764340 than in other patients. Our findings indicate the WWOX SNPs are significantly associated with highly aggressive pathologic features of PCa and an elevated risk of post-RP biochemical recurrence.
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spelling pubmed-102660442023-06-15 WWOX Polymorphisms as Predictors of the Biochemical Recurrence of Localized Prostate Cancer after Radical Prostatectomy Lin, Chia-Yen Wang, Chun-Li Wang, Shian-Shiang Yang, Cheng-Kuang Li, Jian-Ri Chen, Chuan-Shu Hung, Sheng-Chun Chiu, Kun-Yuan Cheng, Chen-Li Ou, Yen-Chuan Yang, Shun-Fa Int J Med Sci Research Paper The downregulation of WW domain-containing oxidoreductase (WWOX), a tumor suppressor gene, is associated with the tumorigenesis and poor prognosis of various cancers. In this study, we investigated the associations between the polymorphisms of WWOX, clinicopathologic features of prostate cancer (PCa), and risk of postoperative biochemical recurrence (BCR). We evaluated the effects of five single-nucleotide polymorphisms (SNPs) of WWOX on the clinicopathologic features of 578 patients with PCa. The risk of postoperative BCR was 2.053-fold higher in patients carrying at least one “A” allele in WWOX rs12918952 than in those with homozygous G/G. Furthermore, patients with at least one polymorphic “T” allele in WWOX rs11545028 had an elevated (1.504-fold) risk of PCa with seminal vesicle invasion. In patients with postoperative BCR, the risks of an advanced Gleason grade and clinical metastasis were 3.317- and 5.259-fold higher in patients carrying at least one “G” allele in WWOX rs3764340 than in other patients. Our findings indicate the WWOX SNPs are significantly associated with highly aggressive pathologic features of PCa and an elevated risk of post-RP biochemical recurrence. Ivyspring International Publisher 2023-05-21 /pmc/articles/PMC10266044/ /pubmed/37324196 http://dx.doi.org/10.7150/ijms.84364 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Lin, Chia-Yen
Wang, Chun-Li
Wang, Shian-Shiang
Yang, Cheng-Kuang
Li, Jian-Ri
Chen, Chuan-Shu
Hung, Sheng-Chun
Chiu, Kun-Yuan
Cheng, Chen-Li
Ou, Yen-Chuan
Yang, Shun-Fa
WWOX Polymorphisms as Predictors of the Biochemical Recurrence of Localized Prostate Cancer after Radical Prostatectomy
title WWOX Polymorphisms as Predictors of the Biochemical Recurrence of Localized Prostate Cancer after Radical Prostatectomy
title_full WWOX Polymorphisms as Predictors of the Biochemical Recurrence of Localized Prostate Cancer after Radical Prostatectomy
title_fullStr WWOX Polymorphisms as Predictors of the Biochemical Recurrence of Localized Prostate Cancer after Radical Prostatectomy
title_full_unstemmed WWOX Polymorphisms as Predictors of the Biochemical Recurrence of Localized Prostate Cancer after Radical Prostatectomy
title_short WWOX Polymorphisms as Predictors of the Biochemical Recurrence of Localized Prostate Cancer after Radical Prostatectomy
title_sort wwox polymorphisms as predictors of the biochemical recurrence of localized prostate cancer after radical prostatectomy
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266044/
https://www.ncbi.nlm.nih.gov/pubmed/37324196
http://dx.doi.org/10.7150/ijms.84364
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