Stroke by inducing HDAC9-dependent deacetylation of HIF-1 and Sp1, promotes TfR1 transcription and GPX4 reduction, thus determining ferroptotic neuronal death

Background: The inhibition of histone deacetylase 9 (HDAC9) represents a promising druggable target for stroke intervention. Indeed, HDAC9 is overexpressed in neurons after brain ischemia where exerts a neurodetrimental role. However, mechanisms of HDAC9-dependent neuronal cell death are not yet wel...

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Detalles Bibliográficos
Autores principales: Sanguigno, Luca, Guida, Natascia, Anzilotti, Serenella, Cuomo, Ornella, Mascolo, Luigi, Serani, Angelo, Brancaccio, Paola, Pennacchio, Giuseppina, Licastro, Ester, Pignataro, Giuseppe, Molinaro, Pasquale, Annunziato, Lucio, Formisano, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266075/
https://www.ncbi.nlm.nih.gov/pubmed/37324938
http://dx.doi.org/10.7150/ijbs.80735

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