Cargando…

TLR9 and STING agonists cooperatively boost the immune response to SARS-CoV-2 RBD vaccine through an increased germinal center B cell response and reshaped T helper responses

Vaccines are a powerful medical intervention for preventing epidemic diseases. Efficient inactivated or protein vaccines typically rely on an effective adjuvant to elicit an immune response and boost vaccine activity. In this study, we investigated the adjuvant activities of combinations of Toll-lik...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Jing-Xing, Tseng, Jen-Chih, Tien, Chih-Feng, Lee, Chia-Yin, Liu, Yi-Ling, Lin, Jhe-Jhih, Tsai, Pei-Ju, Liao, Hung-Chun, Liu, Shih-Jen, Su, Yu-Wen, Hsu, Li-Chung, Chen, Jen-Kun, Huang, Ming-Hsi, Yu, Guann-Yi, Chuang, Tsung-Hsien
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266083/ https://www.ncbi.nlm.nih.gov/pubmed/37324951 http://dx.doi.org/10.7150/ijbs.81210

Ejemplares similares

CpG-oligodeoxynucleotides developed for grouper toll-like receptor (TLR) 21s effectively activate mouse and human TLR9s mediated immune responses
por: Yeh, Da-Wei, et al.
Publicado: (2017)

Comparison of Clinical Manifestations, Treatments, and Outcomes between Vespidae Sting and Formicidae Sting Patients in the Emergency Department in Taiwan
por: Lin, Yen-Yue, et al.
Publicado: (2020)

Degradable emulsion as vaccine adjuvant reshapes antigen-specific immunity and thereby ameliorates vaccine efficacy
por: Huang, Chung-Hsiung, et al.
Publicado: (2016)

STAT2 hinders STING intracellular trafficking and reshapes its activation in response to DNA damage
por: Wang, Chenyao, et al.
Publicado: (2023)

Follicular helper T cells progressively differentiate to regulate the germinal center response
por: Weinstein, Jason S., et al.
Publicado: (2016)

Recombinant SARS-CoV-2 RBD with a built in T helper epitope induces strong neutralization antibody response
por: Su, Qiu-Dong, et al.
Publicado: (2021)

Recombinant lipidated Zika virus envelope protein domain III elicits durable neutralizing antibody responses against Zika virus in mice
por: Chen, Mei-Yu, et al.
Publicado: (2020)

Characterization of Virus Replication, Pathogenesis, and Cytokine Responses in Syrian Hamsters Inoculated with SARS-CoV-2
por: Yang, Shiu-Ju, et al.
Publicado: (2021)

DNA vaccination induced protective immunity against SARS CoV-2 infection in hamsterss
por: Chai, Kit Man, et al.
Publicado: (2021)

Correction: DNA vaccination induced protective immunity against SARS CoV-2 infection in hamsterss
por: Chai, Kit Man, et al.
Publicado: (2023)

Foxp3(+) follicular regulatory T cells control T follicular helper cells and the germinal center response
por: Linterman, Michelle A., et al.
Publicado: (2011)

Decreased T helper 17 cells in tuberculosis is associated with increased percentages of programmed death ligand 1, T helper 2 and regulatory T cells
por: Shu, Chin-Chung, et al.
Publicado: (2017)

TLR4 antagonist suppresses airway remodeling in asthma by inhibiting the T-helper 2 response
por: Li, Ming, et al.
Publicado: (2017)

Neonatal T Follicular Helper Cells Are Lodged in a Pre-T Follicular Helper Stage Favoring Innate Over Adaptive Germinal Center Responses
por: Mastelic-Gavillet, Beatris, et al.
Publicado: (2019)

Recent Advances in the Development of Toll-like Receptor Agonist-Based Vaccine Adjuvants for Infectious Diseases
por: Yang, Jing-Xing, et al.
Publicado: (2022)

Germinal Center B Cell and T Follicular Helper Cell Responses to Viral Vector and Protein-in-Adjuvant Vaccines
por: Wang, Chuan, et al.
Publicado: (2016)

STING Is Required in Conventional Dendritic Cells for DNA Vaccine Induction of Type I T Helper Cell- Dependent Antibody Responses
por: Ulrich-Lewis, Justin Theophilus, et al.
Publicado: (2022)

Formulation of SARS-CoV-2 Spike Protein with CpG Oligodeoxynucleotides and Squalene Nanoparticles Modulates Immunological Aspects Following Intranasal Delivery
por: Ho, Hui-Min, et al.
Publicado: (2022)

Baseline P2Y12 reactivity, kidney function, and CYP2C19 genotype determine clopidogrel responsiveness in acute stroke
por: Lee, Yi-Chung, et al.
Publicado: (2023)

The Effects of Aβ(1-42) Binding to the SARS-CoV-2 Spike Protein S1 Subunit and Angiotensin-Converting Enzyme 2
por: Hsu, John Tsu-An, et al.
Publicado: (2021)

Stress Reshapes the Physiological Response of Halophile Fungi to Salinity
por: Pérez-Llano, Yordanis, et al.
Publicado: (2020)

Pulmonary Infection with Influenza A Virus Induces Site-Specific Germinal Center and T Follicular Helper Cell Responses
por: Boyden, Alexander W., et al.
Publicado: (2012)

Critical roles of mTOR Complex 1 and 2 for T follicular helper cell differentiation and germinal center responses
por: Yang, Jialong, et al.
Publicado: (2016)

Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses
por: Pardi, Norbert, et al.
Publicado: (2018)

TACI Contributes to Plasmodium yoelii Host Resistance by Controlling T Follicular Helper Cell Response and Germinal Center Formation
por: Parra, Marcela, et al.
Publicado: (2018)

T Cell Specific BOB.1/OBF.1 Expression Promotes Germinal Center Response and T Helper Cell Differentiation
por: Betzler, Annika C., et al.
Publicado: (2022)

The Effect of Age, Gender, and Job on Skin Conductance Response among Smartphone Users Who are Prohibited from Using Their Smartphone
por: Hsieh, Hsiu-Fen, et al.
Publicado: (2020)

Glycosylation and S-palmitoylation regulate SARS-CoV-2 spike protein intracellular trafficking
por: Tien, Chih-Feng, et al.
Publicado: (2022)

Nanomedicines targeting activation of STING to reshape tumor immune microenvironment and enhance immunotherapeutic efficacy
por: Chen, Shanshan, et al.
Publicado: (2023)

STING expression and response to treatment with STING ligands in premalignant and malignant disease
por: Baird, Jason R., et al.
Publicado: (2017)

Induction of Immune Responses and Phosphatidylserine Exposure by TLR9 Activation Results in a Cooperative Antitumor Effect with a Phosphatidylserine-targeting Prodrug
por: Tseng, Jen-Chih, et al.
Publicado: (2023)

Cement augmentation for treatment of high to mid-thoracic osteoporotic compression fractures, high-viscosity cement percutaneous vertebroplasty versus balloon kyphoplasty
por: Wu, Shiny Chih-Hsuan, et al.
Publicado: (2022)

Hypoxia-Responsive Subtype Cells Differentiate Into Neurons in the Brain of Zebrafish Embryos Exposed to Hypoxic Stress
por: Zeng, Chih-Wei, et al.
Publicado: (2022)

Priming with rAAV encoding RBD of SARS-CoV S protein and boosting with RBD-specific peptides for T cell epitopes elevated humoral and cellular immune responses against SARS-CoV infection
por: Du, Lanying, et al.
Publicado: (2008)

Jacareubin inhibits TLR4-induced lung inflammatory response caused by the RBD domain of SARS-CoV-2 Spike protein
por: Segura-Villalobos, Deisy, et al.
Publicado: (2022)

Carboxyl-terminal fusion of E7 into Flagellin shifts TLR5 activation to NLRC4/NAIP5 activation and induces TLR5-independent anti-tumor immunity
por: Lin, Kuo-Hsing, et al.
Publicado: (2016)

Reshaping of Bulbar Odor Response by Nasal Flow Rate in the Rat
por: Courtiol, Emmanuelle, et al.
Publicado: (2011)

miRNAs reshape immunity and inflammatory responses in bacterial infection
por: Zhou, Xikun, et al.
Publicado: (2018)

MicroRNAs reshape the immunity of insects in response to bacterial infection
por: Abbas, Muhammad Nadeem, et al.
Publicado: (2023)

Realizing Broadband NIR Photodetection and Ultrahigh Responsivity with Ternary Blend Organic Photodetector
por: Yu, Yang-Yen, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ntp1pshmsd2gllitq5mioskcan