Cargando…

Ability of Local Clearance of Senescent Cells in Ipsilateral Hemisphere to Mitigate Acute Ischemic Brain Injury in Mice

Senolytic treatment has potential therapeutic efficacy for acute ischemic stroke (AIS). However, the systemic treatment of senolytics may produce off-target side effects and a toxic profile, which affect analysis of the role of acute senescence of neuronal cells in pathogenesis of AIS. We constructe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Kuan-Jung, Sheu, Joen-Rong, Teng, Ruei-Dun, Jayakumar, Tanasekar, Chung, Chi-Li, Hsieh, Cheng-Ying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266088/ https://www.ncbi.nlm.nih.gov/pubmed/37324944 http://dx.doi.org/10.7150/ijbs.84060

Ejemplares similares

Mechanisms of TQ-6, a Novel Ruthenium-Derivative Compound, against Lipopolysaccharide-Induced In Vitro Macrophage Activation and Liver Injury in Experimental Mice: The Crucial Role of p38 MAPK and NF-κB Signaling
por: Hsia, Chih-Hsuan, et al.
Publicado: (2018)

Experimental and Clinical Pharmacology of Andrographis paniculata and Its Major Bioactive Phytoconstituent Andrographolide
por: Jayakumar, Thanasekaran, et al.
Publicado: (2013)

HDAC6 dysfunction contributes to impaired maturation of adult neurogenesis in vivo: vital role on functional recovery after ischemic stroke
por: Sheu, Joen-Rong, et al.
Publicado: (2019)

Constraint-induced movement therapy enhances AMPA receptor-dependent synaptic plasticity in the ipsilateral hemisphere following ischemic stroke
por: Hu, Jian, et al.
Publicado: (2020)

Molecular Targets of Natural Products for Chondroprotection in Destructive Joint Diseases
por: Jayakumar, Thanasekaran, et al.
Publicado: (2020)

Activation of Nrf2 by Esculetin Mitigates Inflammatory Responses through Suppression of NF-κB Signaling Cascade in RAW 264.7 Cells
por: Jayakumar, Thanasekaran, et al.
Publicado: (2022)

Inhibitory effect of midazolam on MMP-9, MMP-1 and MMP-13 expression in PMA-stimulated human chondrocytes via recovery of NF-κB signaling
por: Wang, Jen-Jui, et al.
Publicado: (2012)

Synthetic Ruthenium Complex TQ-6 Potently Recovers Cerebral Ischemic Stroke: Attenuation of Microglia and Platelet Activation
por: Hsia, Chih-Hsuan, et al.
Publicado: (2020)

CME‐1, a novel polysaccharide, suppresses iNOS expression in lipopolysaccharide‐stimulated macrophages through ceramide‐initiated protein phosphatase 2A activation
por: Sheu, Joen‐Rong, et al.
Publicado: (2017)

A novel indication of platonin, a therapeutic immunomodulating medicine, on neuroprotection against ischemic stroke in mice
por: Sheu, Joen-Rong, et al.
Publicado: (2017)

Author Correction: A novel indication of platonin, a therapeutic immunomodulating medicine, on neuroprotection against ischemic stroke in mice
por: Sheu, Joen-Rong, et al.
Publicado: (2020)

Metabolite changes in the ipsilateral and contralateral cerebral hemispheres in rats with middle cerebral artery occlusion
por: Ruan, Lei, et al.
Publicado: (2017)

Ipsilateral Hemispheric Brain Atrophy in an Asymptomatic Child With Linear Morphea: A Case Report
por: Albadr, Fahad, et al.
Publicado: (2022)

Astaxanthin, a Carotenoid, Stimulates Immune Responses by Enhancing IFN-γ and IL-2 Secretion in Primary Cultured Lymphocytes in Vitro and ex Vivo
por: Lin, Kuan-Hung, et al.
Publicado: (2015)

Andrographolide induces vascular smooth muscle cell apoptosis through a SHP-1-PP2A-p38MAPK-p53 cascade
por: Chen, Yu-Ying, et al.
Publicado: (2014)

Hemispheric Differences in Ischemic Stroke: Is Left-Hemisphere Stroke More Common?
por: Hedna, Vishnumurthy Shushrutha, et al.
Publicado: (2013)

Antiplatelet Activity of a Newly Synthesized Novel Ruthenium (II): A Potential Role for Akt/JNK Signaling
por: Khamrang, Themmila, et al.
Publicado: (2017)

Decreased (13)N-labeled ammonia uptake in the ipsilateral and contralateral hemispheres following carotid endarterectomy
por: WANG, TAO, et al.
Publicado: (2015)

Hemispheric Differences in Functional Interactions Between the Dorsal Lateral Prefrontal Cortex and Ipsilateral Motor Cortex
por: Wang, Yanqiu, et al.
Publicado: (2020)

Molecular Pharmacology and Pathology of Strokes
por: Sheu, Joen-Rong
Publicado: (2018)

Transcranial Magnetic Mapping of the Short-Latency Modulations of Corticospinal Activity from the Ipsilateral Hemisphere during Rest
por: Cattaneo, Luigi, et al.
Publicado: (2011)

Parietal Activation Associated With Target-Directed Right Hand Movement Is Lateralized by Mirror Feedback to the Ipsilateral Hemisphere
por: Manuweera, Thushini, et al.
Publicado: (2019)

Cooperation Not Competition: Bihemispheric tDCS and fMRI Show Role for Ipsilateral Hemisphere in Motor Learning
por: Waters, Sheena, et al.
Publicado: (2017)

A novel ruthenium (II)-derived organometallic compound, TQ-6, potently inhibits platelet aggregation: Ex vivo and in vivo studies
por: Hsia, Chih-Hsuan, et al.
Publicado: (2017)

Author Correction: A novel ruthenium (II)-derived organometallic compound, TQ-6, potently inhibits platelet aggregation: Ex vivo and in vivo studies
por: Hsia, Chih-Hsuan, et al.
Publicado: (2020)

Excitability of the Motor Cortex Ipsilateral to the Moving Body Side Depends on Spatio-Temporal Task Complexity and Hemispheric Specialization
por: van den Berg, Femke E., et al.
Publicado: (2011)

Commentary: Cooperation Not Competition: Bihemispheric tDCS and fMRI Show Role for Ipsilateral Hemisphere in Motor Learning
por: Hordacre, Brenton, et al.
Publicado: (2018)

Glabridin, a Bioactive Flavonoid from Licorice, Effectively Inhibits Platelet Activation in Humans and Mice
por: Chung, Chi-Li, et al.
Publicado: (2022)

ARF: Connecting senescence and innate immunity for clearance
por: Kearney, Alper Y., et al.
Publicado: (2015)

Systemic clearance of p16(INK4a)‐positive senescent cells mitigates age‐associated intervertebral disc degeneration
por: Patil, Prashanti, et al.
Publicado: (2019)

Hinokitiol Inhibits Migration of A549 Lung Cancer Cells via Suppression of MMPs and Induction of Antioxidant Enzymes and Apoptosis
por: Jayakumar, Thanasekaran, et al.
Publicado: (2018)

A Critical Period for the Development of Schizophrenia-Like Pathology by Aberrant Postnatal Neurogenesis
por: Sheu, Joen-Rong, et al.
Publicado: (2019)

Multi-Targeting Andrographolide, a Novel NF-κB Inhibitor, as a Potential Therapeutic Agent for Stroke
por: Yang, Chih-Hao, et al.
Publicado: (2017)

Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells
por: Ogrodnik, Mikolaj, et al.
Publicado: (2018)

Hemispheric speech lateralisation in the developing brain is related to motor praxis ability
por: Hodgson, Jessica C., et al.
Publicado: (2016)

Possible Molecular Targets of Novel Ruthenium Complexes in Antiplatelet Therapy
por: Jayakumar, Thanasekaran, et al.
Publicado: (2018)

Carbon Dot Nanoparticles Exert Inhibitory Effects on Human Platelets and Reduce Mortality in Mice with Acute Pulmonary Thromboembolism
por: Lee, Tzu-Yin, et al.
Publicado: (2020)

Thrombin Upregulates PAI-1 and Mesothelial–Mesenchymal Transition Through PAR-1 and Contributes to Tuberculous Pleural Fibrosis
por: Hsieh, Cheng-Ying, et al.
Publicado: (2019)

Neuroprotection by the Traditional Chinese Medicine, Tao-Hong-Si-Wu-Tang, against Middle Cerebral Artery Occlusion-Induced Cerebral Ischemia in Rats
por: Wu, Chih-Jen, et al.
Publicado: (2011)

Nobiletin, a citrus flavonoid, activates vasodilator-stimulated phosphoprotein in human platelets through non-cyclic nucleotide-related mechanisms
por: Jayakumar, Thanasekaran, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_tpocjlf3v9tp3oqf6hfvne3fue