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Interventional radiological therapies in colorectal hepatic metastases

Colorectal malignancy is the third most common cancer and one of the prevalent causes of death globally. Around 20-25% of patients present with metastases at the time of diagnosis, and 50-60% of patients develop metastases in due course of the disease. Liver, followed by lung and lymph nodes, are th...

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Autores principales: Vulasala, Sai Swarupa R., Sutphin, Patrick D., Kethu, Samira, Onteddu, Nirmal K., Kalva, Sanjeeva P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266282/
https://www.ncbi.nlm.nih.gov/pubmed/37324012
http://dx.doi.org/10.3389/fonc.2023.963966
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author Vulasala, Sai Swarupa R.
Sutphin, Patrick D.
Kethu, Samira
Onteddu, Nirmal K.
Kalva, Sanjeeva P.
author_facet Vulasala, Sai Swarupa R.
Sutphin, Patrick D.
Kethu, Samira
Onteddu, Nirmal K.
Kalva, Sanjeeva P.
author_sort Vulasala, Sai Swarupa R.
collection PubMed
description Colorectal malignancy is the third most common cancer and one of the prevalent causes of death globally. Around 20-25% of patients present with metastases at the time of diagnosis, and 50-60% of patients develop metastases in due course of the disease. Liver, followed by lung and lymph nodes, are the most common sites of colorectal cancer metastases. In such patients, the 5-year survival rate is approximately 19.2%. Although surgical resection is the primary mode of managing colorectal cancer metastases, only 10-25% of patients are competent for curative therapy. Hepatic insufficiency may be the aftermath of extensive surgical hepatectomy. Hence formal assessment of future liver remnant volume (FLR) is imperative prior to surgery to prevent hepatic failure. The evolution of minimally invasive interventional radiological techniques has enhanced the treatment algorithm of patients with colorectal cancer metastases. Studies have demonstrated that these techniques may address the limitations of curative resection, such as insufficient FLR, bi-lobar disease, and patients at higher risk for surgery. This review focuses on curative and palliative role through procedures including portal vein embolization, radioembolization, and ablation. Alongside, we deliberate various studies on conventional chemoembolization and chemoembolization with irinotecan-loaded drug-eluting beads. The radioembolization with Yttrium-90 microspheres has evolved as salvage therapy in surgically unresectable and chemo-resistant metastases.
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spelling pubmed-102662822023-06-15 Interventional radiological therapies in colorectal hepatic metastases Vulasala, Sai Swarupa R. Sutphin, Patrick D. Kethu, Samira Onteddu, Nirmal K. Kalva, Sanjeeva P. Front Oncol Oncology Colorectal malignancy is the third most common cancer and one of the prevalent causes of death globally. Around 20-25% of patients present with metastases at the time of diagnosis, and 50-60% of patients develop metastases in due course of the disease. Liver, followed by lung and lymph nodes, are the most common sites of colorectal cancer metastases. In such patients, the 5-year survival rate is approximately 19.2%. Although surgical resection is the primary mode of managing colorectal cancer metastases, only 10-25% of patients are competent for curative therapy. Hepatic insufficiency may be the aftermath of extensive surgical hepatectomy. Hence formal assessment of future liver remnant volume (FLR) is imperative prior to surgery to prevent hepatic failure. The evolution of minimally invasive interventional radiological techniques has enhanced the treatment algorithm of patients with colorectal cancer metastases. Studies have demonstrated that these techniques may address the limitations of curative resection, such as insufficient FLR, bi-lobar disease, and patients at higher risk for surgery. This review focuses on curative and palliative role through procedures including portal vein embolization, radioembolization, and ablation. Alongside, we deliberate various studies on conventional chemoembolization and chemoembolization with irinotecan-loaded drug-eluting beads. The radioembolization with Yttrium-90 microspheres has evolved as salvage therapy in surgically unresectable and chemo-resistant metastases. Frontiers Media S.A. 2023-05-30 /pmc/articles/PMC10266282/ /pubmed/37324012 http://dx.doi.org/10.3389/fonc.2023.963966 Text en Copyright © 2023 Vulasala, Sutphin, Kethu, Onteddu and Kalva https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Vulasala, Sai Swarupa R.
Sutphin, Patrick D.
Kethu, Samira
Onteddu, Nirmal K.
Kalva, Sanjeeva P.
Interventional radiological therapies in colorectal hepatic metastases
title Interventional radiological therapies in colorectal hepatic metastases
title_full Interventional radiological therapies in colorectal hepatic metastases
title_fullStr Interventional radiological therapies in colorectal hepatic metastases
title_full_unstemmed Interventional radiological therapies in colorectal hepatic metastases
title_short Interventional radiological therapies in colorectal hepatic metastases
title_sort interventional radiological therapies in colorectal hepatic metastases
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266282/
https://www.ncbi.nlm.nih.gov/pubmed/37324012
http://dx.doi.org/10.3389/fonc.2023.963966
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