Cargando…
Diagnostics and analysis of SARS-CoV-2: current status, recent advances, challenges and perspectives
The disastrous spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has induced severe public healthcare issues and weakened the global economy significantly. Although SARS-CoV-2 infection is not as fatal as the initial outbreak, many infected victims suffer from long COVID. Theref...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266450/ https://www.ncbi.nlm.nih.gov/pubmed/37325147 http://dx.doi.org/10.1039/d2sc06665c |
_version_ | 1785058743348625408 |
---|---|
author | Dong, Tao Wang, Mingyang Liu, Junchong Ma, Pengxin Pang, Shuang Liu, Wanjian Liu, Aihua |
author_facet | Dong, Tao Wang, Mingyang Liu, Junchong Ma, Pengxin Pang, Shuang Liu, Wanjian Liu, Aihua |
author_sort | Dong, Tao |
collection | PubMed |
description | The disastrous spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has induced severe public healthcare issues and weakened the global economy significantly. Although SARS-CoV-2 infection is not as fatal as the initial outbreak, many infected victims suffer from long COVID. Therefore, rapid and large-scale testing is critical in managing patients and alleviating its transmission. Herein, we review the recent advances in techniques to detect SARS-CoV-2. The sensing principles are detailed together with their application domains and analytical performances. In addition, the advantages and limits of each method are discussed and analyzed. Besides molecular diagnostics and antigen and antibody tests, we also review neutralizing antibodies and emerging SARS-CoV-2 variants. Further, the characteristics of the mutational locations in the different variants with epidemiological features are summarized. Finally, the challenges and possible strategies are prospected to develop new assays to meet different diagnostic needs. Thus, this comprehensive and systematic review of SARS-CoV-2 detection technologies may provide insightful guidance and direction for developing tools for the diagnosis and analysis of SARS-CoV-2 to support public healthcare and effective long-term pandemic management and control. |
format | Online Article Text |
id | pubmed-10266450 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-102664502023-06-15 Diagnostics and analysis of SARS-CoV-2: current status, recent advances, challenges and perspectives Dong, Tao Wang, Mingyang Liu, Junchong Ma, Pengxin Pang, Shuang Liu, Wanjian Liu, Aihua Chem Sci Chemistry The disastrous spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has induced severe public healthcare issues and weakened the global economy significantly. Although SARS-CoV-2 infection is not as fatal as the initial outbreak, many infected victims suffer from long COVID. Therefore, rapid and large-scale testing is critical in managing patients and alleviating its transmission. Herein, we review the recent advances in techniques to detect SARS-CoV-2. The sensing principles are detailed together with their application domains and analytical performances. In addition, the advantages and limits of each method are discussed and analyzed. Besides molecular diagnostics and antigen and antibody tests, we also review neutralizing antibodies and emerging SARS-CoV-2 variants. Further, the characteristics of the mutational locations in the different variants with epidemiological features are summarized. Finally, the challenges and possible strategies are prospected to develop new assays to meet different diagnostic needs. Thus, this comprehensive and systematic review of SARS-CoV-2 detection technologies may provide insightful guidance and direction for developing tools for the diagnosis and analysis of SARS-CoV-2 to support public healthcare and effective long-term pandemic management and control. The Royal Society of Chemistry 2023-05-03 /pmc/articles/PMC10266450/ /pubmed/37325147 http://dx.doi.org/10.1039/d2sc06665c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Chemistry Dong, Tao Wang, Mingyang Liu, Junchong Ma, Pengxin Pang, Shuang Liu, Wanjian Liu, Aihua Diagnostics and analysis of SARS-CoV-2: current status, recent advances, challenges and perspectives |
title | Diagnostics and analysis of SARS-CoV-2: current status, recent advances, challenges and perspectives |
title_full | Diagnostics and analysis of SARS-CoV-2: current status, recent advances, challenges and perspectives |
title_fullStr | Diagnostics and analysis of SARS-CoV-2: current status, recent advances, challenges and perspectives |
title_full_unstemmed | Diagnostics and analysis of SARS-CoV-2: current status, recent advances, challenges and perspectives |
title_short | Diagnostics and analysis of SARS-CoV-2: current status, recent advances, challenges and perspectives |
title_sort | diagnostics and analysis of sars-cov-2: current status, recent advances, challenges and perspectives |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266450/ https://www.ncbi.nlm.nih.gov/pubmed/37325147 http://dx.doi.org/10.1039/d2sc06665c |
work_keys_str_mv | AT dongtao diagnosticsandanalysisofsarscov2currentstatusrecentadvanceschallengesandperspectives AT wangmingyang diagnosticsandanalysisofsarscov2currentstatusrecentadvanceschallengesandperspectives AT liujunchong diagnosticsandanalysisofsarscov2currentstatusrecentadvanceschallengesandperspectives AT mapengxin diagnosticsandanalysisofsarscov2currentstatusrecentadvanceschallengesandperspectives AT pangshuang diagnosticsandanalysisofsarscov2currentstatusrecentadvanceschallengesandperspectives AT liuwanjian diagnosticsandanalysisofsarscov2currentstatusrecentadvanceschallengesandperspectives AT liuaihua diagnosticsandanalysisofsarscov2currentstatusrecentadvanceschallengesandperspectives |