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The Impact of Cataracts on the Measurement of Macular Choriocapillaris Flow Deficits Using Swept-Source OCT Angiography

PURPOSE: The impact of cataracts on the measurement of macular choriocapillaris flow deficits (CC FDs) was assessed by comparing the quantitative results before and after cataract surgery using an image quality algorithm developed for swept-source optical coherence tomography angiography (SS-OCTA) s...

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Autores principales: Li, Jianqing, Shen, Mengxi, Cheng, Yuxuan, Zhang, Qinqin, Liu, Jeremy, de Sisternes, Luis, Lewis, Warren H., Wang, Ruikang K., Gregori, Giovanni, Rosenfeld, Philip J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266550/
https://www.ncbi.nlm.nih.gov/pubmed/37306994
http://dx.doi.org/10.1167/tvst.12.6.7
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author Li, Jianqing
Shen, Mengxi
Cheng, Yuxuan
Zhang, Qinqin
Liu, Jeremy
de Sisternes, Luis
Lewis, Warren H.
Wang, Ruikang K.
Gregori, Giovanni
Rosenfeld, Philip J.
author_facet Li, Jianqing
Shen, Mengxi
Cheng, Yuxuan
Zhang, Qinqin
Liu, Jeremy
de Sisternes, Luis
Lewis, Warren H.
Wang, Ruikang K.
Gregori, Giovanni
Rosenfeld, Philip J.
author_sort Li, Jianqing
collection PubMed
description PURPOSE: The impact of cataracts on the measurement of macular choriocapillaris flow deficits (CC FDs) was assessed by comparing the quantitative results before and after cataract surgery using an image quality algorithm developed for swept-source optical coherence tomography angiography (SS-OCTA) scans and a validated strategy for quantifying the CC FDs. METHODS: SS-OCTA image quality scores and CC FDs measurements within the fovea-centered 1-mm, 3-mm, and 5-mm diameter circles were compared before and after cataract surgery. CC FDs changes in a modified Early Treatment Diabetic Retinopathy Study (ETDRS) grid were further investigated. RESULTS: Twenty-four eyes were studied. Overall image quality in all three circles was observed to improve significantly following the removal of cataracts (all P < 0.05). Although there was good repeatability in the measurements of CC FDs at both visits (intraclass correlation coefficients were over 0.95), significant decreases in CC FD measurements were observed after surgery within the 1-mm circle (P < 0.001) and the 3-mm circle (P = 0.011), but no changes were observed within the 5-mm circle (P = 0.509) or any of the quadrant sectors of the modified ETDRS grid (all P > 0.05). CONCLUSIONS: The presence of cataracts resulted in worse image quality and increased CC FD measurements within the fovea-centered 1-mm and 3-mm circles, with the 1-mm circle being impacted the most. TRANSLATIONAL RELEVANCE: The impaired detection of CC perfusion deficits within the central macula of cataract eyes needs to be appreciated when imaging the CC in phakic eyes, especially in clinical trials.
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spelling pubmed-102665502023-06-15 The Impact of Cataracts on the Measurement of Macular Choriocapillaris Flow Deficits Using Swept-Source OCT Angiography Li, Jianqing Shen, Mengxi Cheng, Yuxuan Zhang, Qinqin Liu, Jeremy de Sisternes, Luis Lewis, Warren H. Wang, Ruikang K. Gregori, Giovanni Rosenfeld, Philip J. Transl Vis Sci Technol Retina PURPOSE: The impact of cataracts on the measurement of macular choriocapillaris flow deficits (CC FDs) was assessed by comparing the quantitative results before and after cataract surgery using an image quality algorithm developed for swept-source optical coherence tomography angiography (SS-OCTA) scans and a validated strategy for quantifying the CC FDs. METHODS: SS-OCTA image quality scores and CC FDs measurements within the fovea-centered 1-mm, 3-mm, and 5-mm diameter circles were compared before and after cataract surgery. CC FDs changes in a modified Early Treatment Diabetic Retinopathy Study (ETDRS) grid were further investigated. RESULTS: Twenty-four eyes were studied. Overall image quality in all three circles was observed to improve significantly following the removal of cataracts (all P < 0.05). Although there was good repeatability in the measurements of CC FDs at both visits (intraclass correlation coefficients were over 0.95), significant decreases in CC FD measurements were observed after surgery within the 1-mm circle (P < 0.001) and the 3-mm circle (P = 0.011), but no changes were observed within the 5-mm circle (P = 0.509) or any of the quadrant sectors of the modified ETDRS grid (all P > 0.05). CONCLUSIONS: The presence of cataracts resulted in worse image quality and increased CC FD measurements within the fovea-centered 1-mm and 3-mm circles, with the 1-mm circle being impacted the most. TRANSLATIONAL RELEVANCE: The impaired detection of CC perfusion deficits within the central macula of cataract eyes needs to be appreciated when imaging the CC in phakic eyes, especially in clinical trials. The Association for Research in Vision and Ophthalmology 2023-06-12 /pmc/articles/PMC10266550/ /pubmed/37306994 http://dx.doi.org/10.1167/tvst.12.6.7 Text en Copyright 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Retina
Li, Jianqing
Shen, Mengxi
Cheng, Yuxuan
Zhang, Qinqin
Liu, Jeremy
de Sisternes, Luis
Lewis, Warren H.
Wang, Ruikang K.
Gregori, Giovanni
Rosenfeld, Philip J.
The Impact of Cataracts on the Measurement of Macular Choriocapillaris Flow Deficits Using Swept-Source OCT Angiography
title The Impact of Cataracts on the Measurement of Macular Choriocapillaris Flow Deficits Using Swept-Source OCT Angiography
title_full The Impact of Cataracts on the Measurement of Macular Choriocapillaris Flow Deficits Using Swept-Source OCT Angiography
title_fullStr The Impact of Cataracts on the Measurement of Macular Choriocapillaris Flow Deficits Using Swept-Source OCT Angiography
title_full_unstemmed The Impact of Cataracts on the Measurement of Macular Choriocapillaris Flow Deficits Using Swept-Source OCT Angiography
title_short The Impact of Cataracts on the Measurement of Macular Choriocapillaris Flow Deficits Using Swept-Source OCT Angiography
title_sort impact of cataracts on the measurement of macular choriocapillaris flow deficits using swept-source oct angiography
topic Retina
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266550/
https://www.ncbi.nlm.nih.gov/pubmed/37306994
http://dx.doi.org/10.1167/tvst.12.6.7
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