Recall DNA methylation levels at low coverage sites using a CNN model in WGBS

DNA methylation is an important regulator of gene transcription. WGBS is the gold-standard approach for base-pair resolution quantitative of DNA methylation. It requires high sequencing depth. Many CpG sites with insufficient coverage in the WGBS data, resulting in inaccurate DNA methylation levels...

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Detalles Bibliográficos
Autores principales: Luo, Ximei, Wang, Yansu, Zou, Quan, Xu, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266633/
https://www.ncbi.nlm.nih.gov/pubmed/37315069
http://dx.doi.org/10.1371/journal.pcbi.1011205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266633/
https://www.ncbi.nlm.nih.gov/pubmed/37315069
http://dx.doi.org/10.1371/journal.pcbi.1011205

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