Cargando…
Recall DNA methylation levels at low coverage sites using a CNN model in WGBS
DNA methylation is an important regulator of gene transcription. WGBS is the gold-standard approach for base-pair resolution quantitative of DNA methylation. It requires high sequencing depth. Many CpG sites with insufficient coverage in the WGBS data, resulting in inaccurate DNA methylation levels...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266633/ https://www.ncbi.nlm.nih.gov/pubmed/37315069 http://dx.doi.org/10.1371/journal.pcbi.1011205 |