HIV-1 capsid stability enables inositol phosphate-independent infection of target cells and promotes integration into genes

The mature HIV-1 capsid is stabilized by host and viral determinants. The capsid protein CA binds to the cellular metabolites inositol hexakisphosphate (IP6) and its precursor inositol (1, 3, 4, 5, 6) pentakisphosphate (IP5) to stabilize the mature capsid. In target cells, capsid destabilization by...

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Detalles Bibliográficos
Autores principales: Sowd, Gregory A., Shi, Jiong, Fulmer, Ashley, Aiken, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266667/
https://www.ncbi.nlm.nih.gov/pubmed/37267431
http://dx.doi.org/10.1371/journal.ppat.1011423

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266667/
https://www.ncbi.nlm.nih.gov/pubmed/37267431
http://dx.doi.org/10.1371/journal.ppat.1011423

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