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Somitic positional information guides self-organized patterning of snake scales
Two influential concepts in tissue patterning are Wolpert’s positional information and Turing’s self-organized reaction–diffusion (RD). The latter establishes the patterning of hair and feathers. Here, our morphological, genetic, and functional—by CRISPR-Cas9–mediated gene disruption—characterizatio...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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American Association for the Advancement of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266723/ https://www.ncbi.nlm.nih.gov/pubmed/37315141 http://dx.doi.org/10.1126/sciadv.adf8834 |
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author | Tzika, Athanasia C. Ullate-Agote, Asier Zakany, Szabolcs Kummrow, Maya Milinkovitch, Michel C. |
author_facet | Tzika, Athanasia C. Ullate-Agote, Asier Zakany, Szabolcs Kummrow, Maya Milinkovitch, Michel C. |
author_sort | Tzika, Athanasia C. |
collection | PubMed |
description | Two influential concepts in tissue patterning are Wolpert’s positional information and Turing’s self-organized reaction–diffusion (RD). The latter establishes the patterning of hair and feathers. Here, our morphological, genetic, and functional—by CRISPR-Cas9–mediated gene disruption—characterization of wild-type versus “scaleless” snakes reveals that the near-perfect hexagonal pattern of snake scales is established through interactions between RD in the skin and somitic positional information. First, we show that ventral scale development is guided by hypaxial somites and, second, that ventral scales and epaxial somites guide the sequential RD patterning of the dorsolateral scales. The RD intrinsic length scale evolved to match somite periodicity, ensuring the alignment of ribs and scales, both of which play a critical role in snake locomotion. |
format | Online Article Text |
id | pubmed-10266723 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-102667232023-06-15 Somitic positional information guides self-organized patterning of snake scales Tzika, Athanasia C. Ullate-Agote, Asier Zakany, Szabolcs Kummrow, Maya Milinkovitch, Michel C. Sci Adv Biomedicine and Life Sciences Two influential concepts in tissue patterning are Wolpert’s positional information and Turing’s self-organized reaction–diffusion (RD). The latter establishes the patterning of hair and feathers. Here, our morphological, genetic, and functional—by CRISPR-Cas9–mediated gene disruption—characterization of wild-type versus “scaleless” snakes reveals that the near-perfect hexagonal pattern of snake scales is established through interactions between RD in the skin and somitic positional information. First, we show that ventral scale development is guided by hypaxial somites and, second, that ventral scales and epaxial somites guide the sequential RD patterning of the dorsolateral scales. The RD intrinsic length scale evolved to match somite periodicity, ensuring the alignment of ribs and scales, both of which play a critical role in snake locomotion. American Association for the Advancement of Science 2023-06-14 /pmc/articles/PMC10266723/ /pubmed/37315141 http://dx.doi.org/10.1126/sciadv.adf8834 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Biomedicine and Life Sciences Tzika, Athanasia C. Ullate-Agote, Asier Zakany, Szabolcs Kummrow, Maya Milinkovitch, Michel C. Somitic positional information guides self-organized patterning of snake scales |
title | Somitic positional information guides self-organized patterning of snake scales |
title_full | Somitic positional information guides self-organized patterning of snake scales |
title_fullStr | Somitic positional information guides self-organized patterning of snake scales |
title_full_unstemmed | Somitic positional information guides self-organized patterning of snake scales |
title_short | Somitic positional information guides self-organized patterning of snake scales |
title_sort | somitic positional information guides self-organized patterning of snake scales |
topic | Biomedicine and Life Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266723/ https://www.ncbi.nlm.nih.gov/pubmed/37315141 http://dx.doi.org/10.1126/sciadv.adf8834 |
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