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SMYD2 inhibition–mediated hypomethylation of Ku70 contributes to impaired nonhomologous end joining repair and antitumor immunity

DNA damage repair (DDR) is a double-edged sword with different roles in cancer susceptibility and drug resistance. Recent studies suggest that DDR inhibitors affect immune surveillance. However, this phenomenon is poorly understood. We report that methyltransferase SMYD2 plays an essential role in n...

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Detalles Bibliográficos
Autores principales:	Tang, Ming, Chen, Guofang, Tu, Bo, Hu, Zhiyi, Huang, Yujia, DuFort, Christopher C., Wan, Xiaoping, Mao, Zhiyong, Liu, Yongzhong, Zhu, Wei-Guo, Lu, Wen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266737/ https://www.ncbi.nlm.nih.gov/pubmed/37315132 http://dx.doi.org/10.1126/sciadv.ade6624

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