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Highly piezoelectric, biodegradable, and flexible amino acid nanofibers for medical applications

Amino acid crystals are an attractive piezoelectric material as they have an ultrahigh piezoelectric coefficient and have an appealing safety profile for medical implant applications. Unfortunately, solvent-cast films made from glycine crystals are brittle, quickly dissolve in body fluid, and lack c...

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Autores principales: Chorsi, Meysam T., Le, Thinh T., Lin, Feng, Vinikoor, Tra, Das, Ritopa, Stevens, James F., Mundrane, Caitlyn, Park, Jinyoung, Tran, Khanh T. M., Liu, Yang, Pfund, Jacob, Thompson, Rachel, He, Wu, Jain, Menka, Morales-Acosta, M. Daniela, Bilal, Osama R., Kazerounian, Kazem, Ilies, Horea, Nguyen, Thanh D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266740/
https://www.ncbi.nlm.nih.gov/pubmed/37315129
http://dx.doi.org/10.1126/sciadv.adg6075
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author Chorsi, Meysam T.
Le, Thinh T.
Lin, Feng
Vinikoor, Tra
Das, Ritopa
Stevens, James F.
Mundrane, Caitlyn
Park, Jinyoung
Tran, Khanh T. M.
Liu, Yang
Pfund, Jacob
Thompson, Rachel
He, Wu
Jain, Menka
Morales-Acosta, M. Daniela
Bilal, Osama R.
Kazerounian, Kazem
Ilies, Horea
Nguyen, Thanh D.
author_facet Chorsi, Meysam T.
Le, Thinh T.
Lin, Feng
Vinikoor, Tra
Das, Ritopa
Stevens, James F.
Mundrane, Caitlyn
Park, Jinyoung
Tran, Khanh T. M.
Liu, Yang
Pfund, Jacob
Thompson, Rachel
He, Wu
Jain, Menka
Morales-Acosta, M. Daniela
Bilal, Osama R.
Kazerounian, Kazem
Ilies, Horea
Nguyen, Thanh D.
author_sort Chorsi, Meysam T.
collection PubMed
description Amino acid crystals are an attractive piezoelectric material as they have an ultrahigh piezoelectric coefficient and have an appealing safety profile for medical implant applications. Unfortunately, solvent-cast films made from glycine crystals are brittle, quickly dissolve in body fluid, and lack crystal orientation control, reducing the overall piezoelectric effect. Here, we present a material processing strategy to create biodegradable, flexible, and piezoelectric nanofibers of glycine crystals embedded inside polycaprolactone (PCL). The glycine-PCL nanofiber film exhibits stable piezoelectric performance with a high ultrasound output of 334 kPa [under 0.15 voltage root-mean-square (Vrms)], which outperforms the state-of-the-art biodegradable transducers. We use this material to fabricate a biodegradable ultrasound transducer for facilitating the delivery of chemotherapeutic drug to the brain. The device remarkably enhances the animal survival time (twofold) in mice-bearing orthotopic glioblastoma models. The piezoelectric glycine-PCL presented here could offer an excellent platform not only for glioblastoma therapy but also for developing medical implantation fields.
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spelling pubmed-102667402023-06-15 Highly piezoelectric, biodegradable, and flexible amino acid nanofibers for medical applications Chorsi, Meysam T. Le, Thinh T. Lin, Feng Vinikoor, Tra Das, Ritopa Stevens, James F. Mundrane, Caitlyn Park, Jinyoung Tran, Khanh T. M. Liu, Yang Pfund, Jacob Thompson, Rachel He, Wu Jain, Menka Morales-Acosta, M. Daniela Bilal, Osama R. Kazerounian, Kazem Ilies, Horea Nguyen, Thanh D. Sci Adv Biomedicine and Life Sciences Amino acid crystals are an attractive piezoelectric material as they have an ultrahigh piezoelectric coefficient and have an appealing safety profile for medical implant applications. Unfortunately, solvent-cast films made from glycine crystals are brittle, quickly dissolve in body fluid, and lack crystal orientation control, reducing the overall piezoelectric effect. Here, we present a material processing strategy to create biodegradable, flexible, and piezoelectric nanofibers of glycine crystals embedded inside polycaprolactone (PCL). The glycine-PCL nanofiber film exhibits stable piezoelectric performance with a high ultrasound output of 334 kPa [under 0.15 voltage root-mean-square (Vrms)], which outperforms the state-of-the-art biodegradable transducers. We use this material to fabricate a biodegradable ultrasound transducer for facilitating the delivery of chemotherapeutic drug to the brain. The device remarkably enhances the animal survival time (twofold) in mice-bearing orthotopic glioblastoma models. The piezoelectric glycine-PCL presented here could offer an excellent platform not only for glioblastoma therapy but also for developing medical implantation fields. American Association for the Advancement of Science 2023-06-14 /pmc/articles/PMC10266740/ /pubmed/37315129 http://dx.doi.org/10.1126/sciadv.adg6075 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Biomedicine and Life Sciences
Chorsi, Meysam T.
Le, Thinh T.
Lin, Feng
Vinikoor, Tra
Das, Ritopa
Stevens, James F.
Mundrane, Caitlyn
Park, Jinyoung
Tran, Khanh T. M.
Liu, Yang
Pfund, Jacob
Thompson, Rachel
He, Wu
Jain, Menka
Morales-Acosta, M. Daniela
Bilal, Osama R.
Kazerounian, Kazem
Ilies, Horea
Nguyen, Thanh D.
Highly piezoelectric, biodegradable, and flexible amino acid nanofibers for medical applications
title Highly piezoelectric, biodegradable, and flexible amino acid nanofibers for medical applications
title_full Highly piezoelectric, biodegradable, and flexible amino acid nanofibers for medical applications
title_fullStr Highly piezoelectric, biodegradable, and flexible amino acid nanofibers for medical applications
title_full_unstemmed Highly piezoelectric, biodegradable, and flexible amino acid nanofibers for medical applications
title_short Highly piezoelectric, biodegradable, and flexible amino acid nanofibers for medical applications
title_sort highly piezoelectric, biodegradable, and flexible amino acid nanofibers for medical applications
topic Biomedicine and Life Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266740/
https://www.ncbi.nlm.nih.gov/pubmed/37315129
http://dx.doi.org/10.1126/sciadv.adg6075
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