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Highly piezoelectric, biodegradable, and flexible amino acid nanofibers for medical applications
Amino acid crystals are an attractive piezoelectric material as they have an ultrahigh piezoelectric coefficient and have an appealing safety profile for medical implant applications. Unfortunately, solvent-cast films made from glycine crystals are brittle, quickly dissolve in body fluid, and lack c...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266740/ https://www.ncbi.nlm.nih.gov/pubmed/37315129 http://dx.doi.org/10.1126/sciadv.adg6075 |
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author | Chorsi, Meysam T. Le, Thinh T. Lin, Feng Vinikoor, Tra Das, Ritopa Stevens, James F. Mundrane, Caitlyn Park, Jinyoung Tran, Khanh T. M. Liu, Yang Pfund, Jacob Thompson, Rachel He, Wu Jain, Menka Morales-Acosta, M. Daniela Bilal, Osama R. Kazerounian, Kazem Ilies, Horea Nguyen, Thanh D. |
author_facet | Chorsi, Meysam T. Le, Thinh T. Lin, Feng Vinikoor, Tra Das, Ritopa Stevens, James F. Mundrane, Caitlyn Park, Jinyoung Tran, Khanh T. M. Liu, Yang Pfund, Jacob Thompson, Rachel He, Wu Jain, Menka Morales-Acosta, M. Daniela Bilal, Osama R. Kazerounian, Kazem Ilies, Horea Nguyen, Thanh D. |
author_sort | Chorsi, Meysam T. |
collection | PubMed |
description | Amino acid crystals are an attractive piezoelectric material as they have an ultrahigh piezoelectric coefficient and have an appealing safety profile for medical implant applications. Unfortunately, solvent-cast films made from glycine crystals are brittle, quickly dissolve in body fluid, and lack crystal orientation control, reducing the overall piezoelectric effect. Here, we present a material processing strategy to create biodegradable, flexible, and piezoelectric nanofibers of glycine crystals embedded inside polycaprolactone (PCL). The glycine-PCL nanofiber film exhibits stable piezoelectric performance with a high ultrasound output of 334 kPa [under 0.15 voltage root-mean-square (Vrms)], which outperforms the state-of-the-art biodegradable transducers. We use this material to fabricate a biodegradable ultrasound transducer for facilitating the delivery of chemotherapeutic drug to the brain. The device remarkably enhances the animal survival time (twofold) in mice-bearing orthotopic glioblastoma models. The piezoelectric glycine-PCL presented here could offer an excellent platform not only for glioblastoma therapy but also for developing medical implantation fields. |
format | Online Article Text |
id | pubmed-10266740 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-102667402023-06-15 Highly piezoelectric, biodegradable, and flexible amino acid nanofibers for medical applications Chorsi, Meysam T. Le, Thinh T. Lin, Feng Vinikoor, Tra Das, Ritopa Stevens, James F. Mundrane, Caitlyn Park, Jinyoung Tran, Khanh T. M. Liu, Yang Pfund, Jacob Thompson, Rachel He, Wu Jain, Menka Morales-Acosta, M. Daniela Bilal, Osama R. Kazerounian, Kazem Ilies, Horea Nguyen, Thanh D. Sci Adv Biomedicine and Life Sciences Amino acid crystals are an attractive piezoelectric material as they have an ultrahigh piezoelectric coefficient and have an appealing safety profile for medical implant applications. Unfortunately, solvent-cast films made from glycine crystals are brittle, quickly dissolve in body fluid, and lack crystal orientation control, reducing the overall piezoelectric effect. Here, we present a material processing strategy to create biodegradable, flexible, and piezoelectric nanofibers of glycine crystals embedded inside polycaprolactone (PCL). The glycine-PCL nanofiber film exhibits stable piezoelectric performance with a high ultrasound output of 334 kPa [under 0.15 voltage root-mean-square (Vrms)], which outperforms the state-of-the-art biodegradable transducers. We use this material to fabricate a biodegradable ultrasound transducer for facilitating the delivery of chemotherapeutic drug to the brain. The device remarkably enhances the animal survival time (twofold) in mice-bearing orthotopic glioblastoma models. The piezoelectric glycine-PCL presented here could offer an excellent platform not only for glioblastoma therapy but also for developing medical implantation fields. American Association for the Advancement of Science 2023-06-14 /pmc/articles/PMC10266740/ /pubmed/37315129 http://dx.doi.org/10.1126/sciadv.adg6075 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Biomedicine and Life Sciences Chorsi, Meysam T. Le, Thinh T. Lin, Feng Vinikoor, Tra Das, Ritopa Stevens, James F. Mundrane, Caitlyn Park, Jinyoung Tran, Khanh T. M. Liu, Yang Pfund, Jacob Thompson, Rachel He, Wu Jain, Menka Morales-Acosta, M. Daniela Bilal, Osama R. Kazerounian, Kazem Ilies, Horea Nguyen, Thanh D. Highly piezoelectric, biodegradable, and flexible amino acid nanofibers for medical applications |
title | Highly piezoelectric, biodegradable, and flexible amino acid nanofibers for medical applications |
title_full | Highly piezoelectric, biodegradable, and flexible amino acid nanofibers for medical applications |
title_fullStr | Highly piezoelectric, biodegradable, and flexible amino acid nanofibers for medical applications |
title_full_unstemmed | Highly piezoelectric, biodegradable, and flexible amino acid nanofibers for medical applications |
title_short | Highly piezoelectric, biodegradable, and flexible amino acid nanofibers for medical applications |
title_sort | highly piezoelectric, biodegradable, and flexible amino acid nanofibers for medical applications |
topic | Biomedicine and Life Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266740/ https://www.ncbi.nlm.nih.gov/pubmed/37315129 http://dx.doi.org/10.1126/sciadv.adg6075 |
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