Postoperative risk of IDH-mutant glioma–associated seizures and their potential management with IDH-mutant inhibitors

Seizures are a frequent complication of adult-type diffuse gliomas, and are often difficult to control with medications. Gliomas with mutations in isocitrate dehydrogenase 1 or 2 (IDHmut) are more likely than IDH–wild type (IDHwt) gliomas to cause seizures as part of their initial clinical presentat...

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Detalles Bibliográficos
Autores principales: Drumm, Michael R., Wang, Wenxia, Sears, Thomas K., Bell-Burdett, Kirsten, Javier, Rodrigo, Cotton, Kristen Y., Webb, Brynna, Byrne, Kayla, Unruh, Dusten, Thirunavu, Vineeth, Walshon, Jordain, Steffens, Alicia, McCortney, Kathleen, Lukas, Rimas V., Phillips, Joanna J., Mohamed, Esraa, Finan, John D., Santana-Santos, Lucas, Heimberger, Amy B., Franz, Colin K., Kurz, Jonathan, Templer, Jessica W., Swanson, Geoffrey T., Horbinski, Craig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266777/
https://www.ncbi.nlm.nih.gov/pubmed/37104042
http://dx.doi.org/10.1172/JCI168035

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