Deficiency in the omega-3 lysolipid transporter Mfsd2a leads to aberrant oligodendrocyte lineage development and hypomyelination

Patients with autosomal recessive microcephaly 15 caused by deficiency in the sodium-dependent lysophosphatidylcholine (LPC) transporter major facilitator superfamily domain–containing 2a (Mfsd2a) present with both microcephaly and hypomyelination, suggesting an important role for LPC uptake by olig...

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Detalles Bibliográficos
Autores principales: Sengottuvel, Vetrivel, Hota, Monalisa, Oh, Jeongah, Galam, Dwight L., Wong, Bernice H., Wenk, Markus R., Ghosh, Sujoy, Torta, Federico, Silver, David L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266779/
https://www.ncbi.nlm.nih.gov/pubmed/37104036
http://dx.doi.org/10.1172/JCI164118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266779/
https://www.ncbi.nlm.nih.gov/pubmed/37104036
http://dx.doi.org/10.1172/JCI164118

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