RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia

RAS mutations are among the most prevalent oncogenic drivers in cancers. RAS proteins propagate signals only when associated with cellular membranes as a consequence of lipid modifications that impact their trafficking. Here, we discovered that RAB27B, a RAB family small GTPase, controlled NRAS palm...

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Detalles Bibliográficos
Autores principales: Ren, Jian-Gang, Xing, Bowen, Lv, Kaosheng, O’Keefe, Rachel A., Wu, Mengfang, Wang, Ruoxing, Bauer, Kaylyn M., Ghazaryan, Arevik, Burslem, George M., Zhang, Jing, O’Connell, Ryan M., Pillai, Vinodh, Hexner, Elizabeth O., Philips, Mark R., Tong, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266782/
https://www.ncbi.nlm.nih.gov/pubmed/37317963
http://dx.doi.org/10.1172/JCI165510

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