C5aR1 signaling triggers lung immunopathology in COVID-19 through neutrophil extracellular traps

Patients with severe COVID-19 develop acute respiratory distress syndrome (ARDS) that may progress to cytokine storm syndrome, organ dysfunction, and death. Considering that complement component 5a (C5a), through its cellular receptor C5aR1, has potent proinflammatory actions and plays immunopatholo...

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Detalles Bibliográficos
Autores principales: Silva, Bruna M., Gomes, Giovanni F., Veras, Flavio P., Cambier, Seppe, Silva, Gabriel V.L., Quadros, Andreza U., Caetité, Diego B., Nascimento, Daniele C., Silva, Camilla M., Silva, Juliana C., Damasceno, Samara, Schneider, Ayda H., Beretta, Fabio, Batah, Sabrina S., Castro, Icaro M.S., Paiva, Isadora M., Rodrigues, Tamara, Salina, Ana, Martins, Ronaldo, Cebinelli, Guilherme C.M., Bibo, Naira L., Jorge, Daniel M., Nakaya, Helder I., Zamboni, Dario S., Leiria, Luiz O., Fabro, Alexandre T., Alves-Filho, José C., Arruda, Eurico, Louzada-Junior, Paulo, Oliveira, Renê D., Cunha, Larissa D., Van Mol, Pierre, Vanderbeke, Lore, Feys, Simon, Wauters, Els, Brandolini, Laura, Aramini, Andrea, Cunha, Fernando Q., Köhl, Jörg, Allegretti, Marcello, Lambrechts, Diether, Wauters, Joost, Proost, Paul, Cunha, Thiago M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266787/
https://www.ncbi.nlm.nih.gov/pubmed/37104043
http://dx.doi.org/10.1172/JCI163105

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