An allosteric inhibitor of sirtuin 2 deacetylase activity exhibits broad-spectrum antiviral activity

Most drugs used to treat viral disease target a virus-coded product. They inhibit a single virus or virus family, and the pathogen can readily evolve resistance. Host-targeted antivirals can overcome these limitations. The broad-spectrum activity achieved by host targeting can be especially useful i...

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Detalles Bibliográficos
Autores principales: Roche, Kathryn L., Remiszewski, Stacy, Todd, Matthew J., Kulp, John L., Tang, Liudi, Welsh, Alison V., Barry, Ashley P., De, Chandrav, Reiley, William W., Wahl, Angela, Garcia, J. Victor, Luftig, Micah A., Shenk, Thomas, Tonra, James R., Murphy, Eain A., Chiang, Lillian W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266789/
https://www.ncbi.nlm.nih.gov/pubmed/37317966
http://dx.doi.org/10.1172/JCI158978

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