Viral vector–mediated expression of Na(V)1.1, after seizure onset, reduces epilepsy in mice with Dravet syndrome

Dravet syndrome (DS), an intractable childhood epileptic encephalopathy with a high fatality rate, is typically caused by loss-of-function mutations in one allele of SCN1A, which encodes Na(V)1.1, a 250-kDa voltage-gated sodium channel. In contrast to other epilepsies, pharmaceutical treatment for D...

Descripción completa

Detalles Bibliográficos
Autores principales: Fadila, Saja, Beucher, Bertrand, Dopeso-Reyes, Iria González, Mavashov, Anat, Brusel, Marina, Anderson, Karen, Ismeurt, Caroline, Goldberg, Ethan M., Ricobaraza, Ana, Hernandez-Alcoceba, Ruben, Kremer, Eric J., Rubinstein, Moran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266792/
https://www.ncbi.nlm.nih.gov/pubmed/37192002
http://dx.doi.org/10.1172/JCI159316

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266792/
https://www.ncbi.nlm.nih.gov/pubmed/37192002
http://dx.doi.org/10.1172/JCI159316

Ejemplares similares