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Etiology, effects and management of comorbidities in multiple sclerosis: recent advances

Comorbid conditions commonly affect people with multiple sclerosis (MS). Population-based studies indicate that people with MS have an increased incidence of ischemic heart disease, cerebrovascular disease, peripheral vascular disease, and psychiatric disorders as compared to people without MS. Peop...

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Autores principales: Marrie, Ruth Ann, Fisk, John D., Fitzgerald, Kathryn, Kowalec, Kaarina, Maxwell, Colleen, Rotstein, Dalia, Salter, Amber, Tremlett, Helen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266935/
https://www.ncbi.nlm.nih.gov/pubmed/37325663
http://dx.doi.org/10.3389/fimmu.2023.1197195
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author Marrie, Ruth Ann
Fisk, John D.
Fitzgerald, Kathryn
Kowalec, Kaarina
Maxwell, Colleen
Rotstein, Dalia
Salter, Amber
Tremlett, Helen
author_facet Marrie, Ruth Ann
Fisk, John D.
Fitzgerald, Kathryn
Kowalec, Kaarina
Maxwell, Colleen
Rotstein, Dalia
Salter, Amber
Tremlett, Helen
author_sort Marrie, Ruth Ann
collection PubMed
description Comorbid conditions commonly affect people with multiple sclerosis (MS). Population-based studies indicate that people with MS have an increased incidence of ischemic heart disease, cerebrovascular disease, peripheral vascular disease, and psychiatric disorders as compared to people without MS. People with MS from underrepresented minority and immigrant groups have higher comorbidity burdens. Comorbidities exert effects throughout the disease course, from symptom onset through diagnosis to the end of life. At the individual level, comorbidity is associated with higher relapse rates, greater physical and cognitive impairments, lower health-related quality of life, and increased mortality. At the level of the health system and society, comorbidity is associated with increased health care utilization, costs and work impairment. A nascent literature suggests that MS affects outcomes from comorbidities. Comorbidity management needs to be integrated into MS care, and this would be facilitated by determining optimal models of care.
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spelling pubmed-102669352023-06-15 Etiology, effects and management of comorbidities in multiple sclerosis: recent advances Marrie, Ruth Ann Fisk, John D. Fitzgerald, Kathryn Kowalec, Kaarina Maxwell, Colleen Rotstein, Dalia Salter, Amber Tremlett, Helen Front Immunol Immunology Comorbid conditions commonly affect people with multiple sclerosis (MS). Population-based studies indicate that people with MS have an increased incidence of ischemic heart disease, cerebrovascular disease, peripheral vascular disease, and psychiatric disorders as compared to people without MS. People with MS from underrepresented minority and immigrant groups have higher comorbidity burdens. Comorbidities exert effects throughout the disease course, from symptom onset through diagnosis to the end of life. At the individual level, comorbidity is associated with higher relapse rates, greater physical and cognitive impairments, lower health-related quality of life, and increased mortality. At the level of the health system and society, comorbidity is associated with increased health care utilization, costs and work impairment. A nascent literature suggests that MS affects outcomes from comorbidities. Comorbidity management needs to be integrated into MS care, and this would be facilitated by determining optimal models of care. Frontiers Media S.A. 2023-05-30 /pmc/articles/PMC10266935/ /pubmed/37325663 http://dx.doi.org/10.3389/fimmu.2023.1197195 Text en Copyright © 2023 Marrie, Fisk, Fitzgerald, Kowalec, Maxwell, Rotstein, Salter and Tremlett https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Marrie, Ruth Ann
Fisk, John D.
Fitzgerald, Kathryn
Kowalec, Kaarina
Maxwell, Colleen
Rotstein, Dalia
Salter, Amber
Tremlett, Helen
Etiology, effects and management of comorbidities in multiple sclerosis: recent advances
title Etiology, effects and management of comorbidities in multiple sclerosis: recent advances
title_full Etiology, effects and management of comorbidities in multiple sclerosis: recent advances
title_fullStr Etiology, effects and management of comorbidities in multiple sclerosis: recent advances
title_full_unstemmed Etiology, effects and management of comorbidities in multiple sclerosis: recent advances
title_short Etiology, effects and management of comorbidities in multiple sclerosis: recent advances
title_sort etiology, effects and management of comorbidities in multiple sclerosis: recent advances
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266935/
https://www.ncbi.nlm.nih.gov/pubmed/37325663
http://dx.doi.org/10.3389/fimmu.2023.1197195
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