Interleukin 18 (IL-18) and IL-3 in Extracellular Vesicles: Biomarkers for Durable Elite Control of HIV-1

Plasma extracellular vesicle (EV)-associated cytokines were quantified in people with HIV (PWH) with different virological control status, including elite controllers (EC) who maintain persistent control (PC) or not (TC). Cytokine signatures and pathways were determined for each group. Median EV-ass...

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Autores principales: Poveda, Eva, Fitzgerald, Wendy, Reglero, Cristina, Pérez-González, Alexandre, Mariño, Ana, Álvarez, Hortensia, Valcarce, Nieves, Llibre, Josep Maria, Guillén, Santiago Moreno, Muñoz Fernández, Maria Angeles, Ruiz-Mateos, Ezequiel, Margolis, Leonid, Lederman, Michael M, Freeman, Michael L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266942/
https://www.ncbi.nlm.nih.gov/pubmed/36790818
http://dx.doi.org/10.1093/infdis/jiad042
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author Poveda, Eva
Fitzgerald, Wendy
Reglero, Cristina
Pérez-González, Alexandre
Mariño, Ana
Álvarez, Hortensia
Valcarce, Nieves
Llibre, Josep Maria
Guillén, Santiago Moreno
Muñoz Fernández, Maria Angeles
Ruiz-Mateos, Ezequiel
Margolis, Leonid
Lederman, Michael M
Freeman, Michael L
author_facet Poveda, Eva
Fitzgerald, Wendy
Reglero, Cristina
Pérez-González, Alexandre
Mariño, Ana
Álvarez, Hortensia
Valcarce, Nieves
Llibre, Josep Maria
Guillén, Santiago Moreno
Muñoz Fernández, Maria Angeles
Ruiz-Mateos, Ezequiel
Margolis, Leonid
Lederman, Michael M
Freeman, Michael L
author_sort Poveda, Eva
collection PubMed
description Plasma extracellular vesicle (EV)-associated cytokines were quantified in people with HIV (PWH) with different virological control status, including elite controllers (EC) who maintain persistent control (PC) or not (TC). Cytokine signatures and pathways were determined for each group. Median EV-associated cytokine levels were higher among PWH than HIV-uninfected. EC showed the highest levels of EV-associated cytokines among PWH with PC levels higher than TC levels. IL-18 levels best distinguished PWH from uninfected controls, and EC from ART-treated, and IL-3 distinguished PC from TC. The role of EV-cytokines in intercellular communication and endogenous control of HIV expression should be investigated further.
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spelling pubmed-102669422023-06-15 Interleukin 18 (IL-18) and IL-3 in Extracellular Vesicles: Biomarkers for Durable Elite Control of HIV-1 Poveda, Eva Fitzgerald, Wendy Reglero, Cristina Pérez-González, Alexandre Mariño, Ana Álvarez, Hortensia Valcarce, Nieves Llibre, Josep Maria Guillén, Santiago Moreno Muñoz Fernández, Maria Angeles Ruiz-Mateos, Ezequiel Margolis, Leonid Lederman, Michael M Freeman, Michael L J Infect Dis Brief Report Plasma extracellular vesicle (EV)-associated cytokines were quantified in people with HIV (PWH) with different virological control status, including elite controllers (EC) who maintain persistent control (PC) or not (TC). Cytokine signatures and pathways were determined for each group. Median EV-associated cytokine levels were higher among PWH than HIV-uninfected. EC showed the highest levels of EV-associated cytokines among PWH with PC levels higher than TC levels. IL-18 levels best distinguished PWH from uninfected controls, and EC from ART-treated, and IL-3 distinguished PC from TC. The role of EV-cytokines in intercellular communication and endogenous control of HIV expression should be investigated further. Oxford University Press 2023-02-15 /pmc/articles/PMC10266942/ /pubmed/36790818 http://dx.doi.org/10.1093/infdis/jiad042 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Poveda, Eva
Fitzgerald, Wendy
Reglero, Cristina
Pérez-González, Alexandre
Mariño, Ana
Álvarez, Hortensia
Valcarce, Nieves
Llibre, Josep Maria
Guillén, Santiago Moreno
Muñoz Fernández, Maria Angeles
Ruiz-Mateos, Ezequiel
Margolis, Leonid
Lederman, Michael M
Freeman, Michael L
Interleukin 18 (IL-18) and IL-3 in Extracellular Vesicles: Biomarkers for Durable Elite Control of HIV-1
title Interleukin 18 (IL-18) and IL-3 in Extracellular Vesicles: Biomarkers for Durable Elite Control of HIV-1
title_full Interleukin 18 (IL-18) and IL-3 in Extracellular Vesicles: Biomarkers for Durable Elite Control of HIV-1
title_fullStr Interleukin 18 (IL-18) and IL-3 in Extracellular Vesicles: Biomarkers for Durable Elite Control of HIV-1
title_full_unstemmed Interleukin 18 (IL-18) and IL-3 in Extracellular Vesicles: Biomarkers for Durable Elite Control of HIV-1
title_short Interleukin 18 (IL-18) and IL-3 in Extracellular Vesicles: Biomarkers for Durable Elite Control of HIV-1
title_sort interleukin 18 (il-18) and il-3 in extracellular vesicles: biomarkers for durable elite control of hiv-1
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266942/
https://www.ncbi.nlm.nih.gov/pubmed/36790818
http://dx.doi.org/10.1093/infdis/jiad042
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