Unravelling the genetic architecture of human complex traits through whole genome sequencing

Whole genome sequencing has enabled new insights into the genetic architecture of complex traits, especially through access to low-frequency and rare variation. This Comment highlights the key contributions from this technology and discusses considerations for its use and future perspectives.

Detalles Bibliográficos
Autores principales: Bocher, Ozvan, Willer, Cristen J., Zeggini, Eleftheria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267118/
https://www.ncbi.nlm.nih.gov/pubmed/37316478
http://dx.doi.org/10.1038/s41467-023-39259-x
_version_ 1785058863001632768
author Bocher, Ozvan
Willer, Cristen J.
Zeggini, Eleftheria
author_facet Bocher, Ozvan
Willer, Cristen J.
Zeggini, Eleftheria
author_sort Bocher, Ozvan
collection PubMed
description Whole genome sequencing has enabled new insights into the genetic architecture of complex traits, especially through access to low-frequency and rare variation. This Comment highlights the key contributions from this technology and discusses considerations for its use and future perspectives.
format Online
Article
Text
id pubmed-10267118
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-102671182023-06-15 Unravelling the genetic architecture of human complex traits through whole genome sequencing Bocher, Ozvan Willer, Cristen J. Zeggini, Eleftheria Nat Commun Comment Whole genome sequencing has enabled new insights into the genetic architecture of complex traits, especially through access to low-frequency and rare variation. This Comment highlights the key contributions from this technology and discusses considerations for its use and future perspectives. Nature Publishing Group UK 2023-06-14 /pmc/articles/PMC10267118/ /pubmed/37316478 http://dx.doi.org/10.1038/s41467-023-39259-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Comment
Bocher, Ozvan
Willer, Cristen J.
Zeggini, Eleftheria
Unravelling the genetic architecture of human complex traits through whole genome sequencing
title Unravelling the genetic architecture of human complex traits through whole genome sequencing
title_full Unravelling the genetic architecture of human complex traits through whole genome sequencing
title_fullStr Unravelling the genetic architecture of human complex traits through whole genome sequencing
title_full_unstemmed Unravelling the genetic architecture of human complex traits through whole genome sequencing
title_short Unravelling the genetic architecture of human complex traits through whole genome sequencing
title_sort unravelling the genetic architecture of human complex traits through whole genome sequencing
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267118/
https://www.ncbi.nlm.nih.gov/pubmed/37316478
http://dx.doi.org/10.1038/s41467-023-39259-x
work_keys_str_mv AT bocherozvan unravellingthegeneticarchitectureofhumancomplextraitsthroughwholegenomesequencing
AT willercristenj unravellingthegeneticarchitectureofhumancomplextraitsthroughwholegenomesequencing
AT zegginieleftheria unravellingthegeneticarchitectureofhumancomplextraitsthroughwholegenomesequencing

Ejemplares similares