SMURF1 attenuates endoplasmic reticulum stress by promoting the degradation of KEAP1 to activate NRF2 antioxidant pathway

Cancer cells consistently utilize the unfolded protein response (UPR) to encounter the abnormal endoplasmic reticulum (ER) stress induced by the accumulation of misfolded proteins. Extreme activation of the UPR could also provoke maladaptive cell death. Previous reports have shown that NRF2 antioxid...

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Detalles Bibliográficos
Autores principales: Dong, Lei, Xu, Mengchuan, Li, Yang, Xu, Wanting, Wu, Chengwei, Zheng, Hanfei, Xiao, Zhenyu, Sun, Guochen, Ding, Lei, Li, Xiaobo, Li, Wenming, Zhou, Liying, Xia, Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267134/
https://www.ncbi.nlm.nih.gov/pubmed/37316499
http://dx.doi.org/10.1038/s41419-023-05873-2

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