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The structure of phosphatidylinositol remodeling MBOAT7 reveals its catalytic mechanism and enables inhibitor identification

Cells remodel glycerophospholipid acyl chains via the Lands cycle to adjust membrane properties. Membrane-bound O-acyltransferase (MBOAT) 7 acylates lyso-phosphatidylinositol (lyso-PI) with arachidonyl-CoA. MBOAT7 mutations cause brain developmental disorders, and reduced expression is linked to fat...

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Detalles Bibliográficos
Autores principales:	Wang, Kun, Lee, Chia-Wei, Sui, Xuewu, Kim, Siyoung, Wang, Shuhui, Higgs, Aidan B., Baublis, Aaron J., Voth, Gregory A., Liao, Maofu, Walther, Tobias C., Farese, Robert V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267149/ https://www.ncbi.nlm.nih.gov/pubmed/37316513 http://dx.doi.org/10.1038/s41467-023-38932-5

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